CAS OpenIR
Functional Nanomaterials Based on Self-Assembly of Endogenic NIR-Absorbing Pigments for Diagnostic and Therapeutic Applications
Zou, Qianli1; Bao, Jianwei1; Yan, Xuehai1,2
2022-02-10
Source PublicationSMALL METHODS
ISSN2366-9608
Pages17
AbstractEndogenic pigments derived from hemoglobin have been successfully applied in the clinic for both imaging and therapy based on their inherent photophysical and photochemical properties, including light absorption, fluorescence emission, and producing reactive oxygen species. However, the clinically approved endogenic pigments can be excited only by UV/vis light, restricting the penetration depth of in vivo applications. Recently, endogenic pigments with NIR-absorbing properties have been explored for constructing functional nanomaterials. Here, the overview of NIR-absorbing endogenic pigments, mainly bile pigments, and melanins, as emerging building blocks for supramolecular construction of diagnostic and therapeutic nanomaterials is provided. The endogenic origins, synthetic pathways, and structural characteristics of the NIR-absorbing endogenic pigments are described. The self-assembling approaches and noncovalent interactions in fabricating the nanomaterials are emphasized. Since bile pigments and melanins are inherently photothermal agents, the resulting nanomaterials are demonstrated as promising candidates for photoacoustic imaging and photothermal therapy. Integration of additional diagnostic and therapeutic agents by the nanomaterials through chemical conjugation or physical encapsulation toward synergetic effects is also included. Especially, the degradation behaviors of the nanomaterials in biological environments are summarized. Along with the challenges, future perspectives are discussed for accelerating the ration design and clinical translation of NIR-absorbing nanomaterials.
Keywordendogenic pigments NIR-absorbing nanomaterials photoacoustic imaging photothermal therapy self-assembly
DOI10.1002/smtd.202101359
Language英语
WOS KeywordSEMICONDUCTING POLYMER NANOPARTICLES ; CAMOUFLAGED MELANIN NANOPARTICLES ; PHOTOTHERMAL THERAPY ; BILIRUBIN NANOPARTICLES ; PHOTODYNAMIC THERAPY ; PORPHYRIN ; EFFICIENT ; PHOTOSENSITIZERS ; NANOMEDICINE ; PROTEIN
Funding ProjectNational Science Fund for Distinguished Young Scholars of China[22025207] ; National Natural Science Foundation of China[21773248] ; National Natural Science Foundation of China[21977095] ; National Natural Science Fund BRICS STI Framework Programme[51861145304] ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS)[QYZDBSSW-JSC034] ; Natural Science Foundation for Distinguished Young Scholars of Anhui Province[2108085J41] ; Grants for Scientific Research of BSKY from Anhui Medical University[XJ2020022]
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
WOS SubjectChemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
Funding OrganizationNational Science Fund for Distinguished Young Scholars of China ; National Natural Science Foundation of China ; National Natural Science Fund BRICS STI Framework Programme ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS) ; Natural Science Foundation for Distinguished Young Scholars of Anhui Province ; Grants for Scientific Research of BSKY from Anhui Medical University
WOS IDWOS:000753369300001
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/51974
Collection中国科学院过程工程研究所
Corresponding AuthorZou, Qianli; Yan, Xuehai
Affiliation1.Anhui Med Univ, Sch Pharm, Hefei 230032, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Zou, Qianli,Bao, Jianwei,Yan, Xuehai. Functional Nanomaterials Based on Self-Assembly of Endogenic NIR-Absorbing Pigments for Diagnostic and Therapeutic Applications[J]. SMALL METHODS,2022:17.
APA Zou, Qianli,Bao, Jianwei,&Yan, Xuehai.(2022).Functional Nanomaterials Based on Self-Assembly of Endogenic NIR-Absorbing Pigments for Diagnostic and Therapeutic Applications.SMALL METHODS,17.
MLA Zou, Qianli,et al."Functional Nanomaterials Based on Self-Assembly of Endogenic NIR-Absorbing Pigments for Diagnostic and Therapeutic Applications".SMALL METHODS (2022):17.
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