Knowledge Management System Of Institute of process engineering,CAS
| Functional Nanomaterials Based on Self-Assembly of Endogenic NIR-Absorbing Pigments for Diagnostic and Therapeutic Applications | |
| Zou, Qianli1; Bao, Jianwei1; Yan, Xuehai1,2 | |
| 2022-02-10 | |
| Source Publication | SMALL METHODS
 |
| ISSN | 2366-9608 |
| Pages | 17 |
| Abstract | Endogenic pigments derived from hemoglobin have been successfully applied in the clinic for both imaging and therapy based on their inherent photophysical and photochemical properties, including light absorption, fluorescence emission, and producing reactive oxygen species. However, the clinically approved endogenic pigments can be excited only by UV/vis light, restricting the penetration depth of in vivo applications. Recently, endogenic pigments with NIR-absorbing properties have been explored for constructing functional nanomaterials. Here, the overview of NIR-absorbing endogenic pigments, mainly bile pigments, and melanins, as emerging building blocks for supramolecular construction of diagnostic and therapeutic nanomaterials is provided. The endogenic origins, synthetic pathways, and structural characteristics of the NIR-absorbing endogenic pigments are described. The self-assembling approaches and noncovalent interactions in fabricating the nanomaterials are emphasized. Since bile pigments and melanins are inherently photothermal agents, the resulting nanomaterials are demonstrated as promising candidates for photoacoustic imaging and photothermal therapy. Integration of additional diagnostic and therapeutic agents by the nanomaterials through chemical conjugation or physical encapsulation toward synergetic effects is also included. Especially, the degradation behaviors of the nanomaterials in biological environments are summarized. Along with the challenges, future perspectives are discussed for accelerating the ration design and clinical translation of NIR-absorbing nanomaterials. |
| Keyword | endogenic pigments NIR-absorbing nanomaterials photoacoustic imaging photothermal therapy self-assembly |
| DOI | 10.1002/smtd.202101359 |
| Language | 英语 |
| WOS Keyword | SEMICONDUCTING POLYMER NANOPARTICLES ; CAMOUFLAGED MELANIN NANOPARTICLES ; PHOTOTHERMAL THERAPY ; BILIRUBIN NANOPARTICLES ; PHOTODYNAMIC THERAPY ; PORPHYRIN ; EFFICIENT ; PHOTOSENSITIZERS ; NANOMEDICINE ; PROTEIN |
| Funding Project | National Science Fund for Distinguished Young Scholars of China[22025207] ; National Natural Science Foundation of China[21773248] ; National Natural Science Foundation of China[21977095] ; National Natural Science Fund BRICS STI Framework Programme[51861145304] ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS)[QYZDBSSW-JSC034] ; Natural Science Foundation for Distinguished Young Scholars of Anhui Province[2108085J41] ; Grants for Scientific Research of BSKY from Anhui Medical University[XJ2020022] |
| WOS Research Area | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| WOS Subject | Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| Funding Organization | National Science Fund for Distinguished Young Scholars of China ; National Natural Science Foundation of China ; National Natural Science Fund BRICS STI Framework Programme ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS) ; Natural Science Foundation for Distinguished Young Scholars of Anhui Province ; Grants for Scientific Research of BSKY from Anhui Medical University |
| WOS ID | WOS:000753369300001 |
| Publisher | WILEY-V C H VERLAG GMBH |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/51974 |
| Collection | 中国科学院过程工程研究所 |
| Corresponding Author | Zou, Qianli; Yan, Xuehai |
| Affiliation | 1.Anhui Med Univ, Sch Pharm, Hefei 230032, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China |
| Corresponding Author Affilication | Center of lonic Liquids and Green Engineering |
| Recommended Citation GB/T 7714 | Zou, Qianli,Bao, Jianwei,Yan, Xuehai. Functional Nanomaterials Based on Self-Assembly of Endogenic NIR-Absorbing Pigments for Diagnostic and Therapeutic Applications[J]. SMALL METHODS,2022:17. |
| APA | Zou, Qianli,Bao, Jianwei,&Yan, Xuehai.(2022).Functional Nanomaterials Based on Self-Assembly of Endogenic NIR-Absorbing Pigments for Diagnostic and Therapeutic Applications.SMALL METHODS,17. |
| MLA | Zou, Qianli,et al."Functional Nanomaterials Based on Self-Assembly of Endogenic NIR-Absorbing Pigments for Diagnostic and Therapeutic Applications".SMALL METHODS (2022):17. |
| Files in This Item: | There are no files associated with this item. | |||||
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment