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Immobilized arginine/tryptophan-rich cyclic dodecapeptide on reduced graphene oxide anchored with manganese dioxide for microbial biofilm eradication
Samak, Nadia A.1,2,4,6,7; Selim, Mohamed S.3,5; Hao, Zhifeng3; Xing, Jianmin1,2,7,8
2022-03-15
Source PublicationJOURNAL OF HAZARDOUS MATERIALS
ISSN0304-3894
Volume426Pages:15
AbstractTo avoid the accumulation of bacterial biofilms in water pipelines, it is critical to develop potent antimicrobial agents with good ability to reduce extracellular polymeric substances (EPS). In this study, cyclic dodecapeptides were synthesized, and different mutations for increasing the ratio of arginine (Arg) and tryptophan (Trp) were introduced. Separately, the synthesized dodecapeptides were immobilized on a reduced graphene oxide nanocomposite anchored with a hierarchical beta-MnO2 (RGO/beta-MnO2) hybrid. With a minimum inhibitory concentration of 0.97 g/mL, the immobilized Arg-Trp rich antimicrobial peptides (AMP) on RGO/MnO2 nanocomposite, Cdp-4/RGO/MnO2, showed superior efficacy against multidrug-resistant Pseudomonas aeruginosa ATCC 15692 (P. aeruginosa) planktonic cells. The immobilized Cdp-4/RGO/beta-MnO2 also eradicated the mature biofilm by 99% with a minimum inhibitory concentration value of 62.5 mu g/mL with significant reduction of EPS. These characteristics allow the use of the immobilized Arg-Trp rich AMP as a promising antimicrobial agent against microbial biofilms, present in water distribution systems.
KeywordAntimicrobial peptides Arginine-tryptophan-rich dodecapeptides Pseudomonas aeruginosa Biofilms Water distribution systems
DOI10.1016/j.jhazmat.2021.128035
Language英语
WOS KeywordPSEUDOMONAS-AERUGINOSA ; ANTIMICROBIAL PEPTIDES ; ANTIBACTERIAL ACTIVITY ; SILVER ; METAL ; NANOPARTICLES ; COMPOSITE ; CARBON ; CELLS
Funding ProjectApplied Science and Technology Research and Development Special Foundation of Guangdong Province[2016B090930004] ; China Postdoctoral Science Foundation's 65th Batch of General Aid[2019M652822]
WOS Research AreaEngineering ; Environmental Sciences & Ecology
WOS SubjectEngineering, Environmental ; Environmental Sciences
Funding OrganizationApplied Science and Technology Research and Development Special Foundation of Guangdong Province ; China Postdoctoral Science Foundation's 65th Batch of General Aid
WOS IDWOS:000752476800002
PublisherELSEVIER
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Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/51981
Collection中国科学院过程工程研究所
Corresponding AuthorHao, Zhifeng; Xing, Jianmin
Affiliation1.Chinese Acad Sci, CAS Key Lab Green Proc & Engn, Inst Proc Engn, Beijing 100190, Peoples R China
2.Chinese Acad Sci, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
3.Guangdong Univ Technol, Sch Chem Engn & Light Ind, Guangdong Prov Key Lab Plant Resources Biorefiner, Guangzhou 510006, Peoples R China
4.Univ Duisburg Essen, Aquat Microbiol, Environm Microbiol & Biotechnol, D-4141 Essen, Germany
5.Egyptian Petr Res Inst, Petr Applicat Dept, Cairo 11727, Egypt
6.Egyptian Petr Res Inst, Proc Design & Dev Dept, Cairo 11727, Egypt
7.Univ Chinese Acad Sci, Coll Chem Engn, Beijing 100049, Peoples R China
8.Chem & Chem Engn Guangdong Lab, Shantou 515031, Peoples R China
Recommended Citation
GB/T 7714
Samak, Nadia A.,Selim, Mohamed S.,Hao, Zhifeng,et al. Immobilized arginine/tryptophan-rich cyclic dodecapeptide on reduced graphene oxide anchored with manganese dioxide for microbial biofilm eradication[J]. JOURNAL OF HAZARDOUS MATERIALS,2022,426:15.
APA Samak, Nadia A.,Selim, Mohamed S.,Hao, Zhifeng,&Xing, Jianmin.(2022).Immobilized arginine/tryptophan-rich cyclic dodecapeptide on reduced graphene oxide anchored with manganese dioxide for microbial biofilm eradication.JOURNAL OF HAZARDOUS MATERIALS,426,15.
MLA Samak, Nadia A.,et al."Immobilized arginine/tryptophan-rich cyclic dodecapeptide on reduced graphene oxide anchored with manganese dioxide for microbial biofilm eradication".JOURNAL OF HAZARDOUS MATERIALS 426(2022):15.
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