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| Immobilized arginine/tryptophan-rich cyclic dodecapeptide on reduced graphene oxide anchored with manganese dioxide for microbial biofilm eradication | |
Samak, Nadia A.1,2,4,6,7; Selim, Mohamed S.3,5; Hao, Zhifeng3; Xing, Jianmin1,2,7,8
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| 2022-03-15 | |
| Source Publication | JOURNAL OF HAZARDOUS MATERIALS
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| ISSN | 0304-3894 |
| Volume | 426Pages:15 |
| Abstract | To avoid the accumulation of bacterial biofilms in water pipelines, it is critical to develop potent antimicrobial agents with good ability to reduce extracellular polymeric substances (EPS). In this study, cyclic dodecapeptides were synthesized, and different mutations for increasing the ratio of arginine (Arg) and tryptophan (Trp) were introduced. Separately, the synthesized dodecapeptides were immobilized on a reduced graphene oxide nanocomposite anchored with a hierarchical beta-MnO2 (RGO/beta-MnO2) hybrid. With a minimum inhibitory concentration of 0.97 g/mL, the immobilized Arg-Trp rich antimicrobial peptides (AMP) on RGO/MnO2 nanocomposite, Cdp-4/RGO/MnO2, showed superior efficacy against multidrug-resistant Pseudomonas aeruginosa ATCC 15692 (P. aeruginosa) planktonic cells. The immobilized Cdp-4/RGO/beta-MnO2 also eradicated the mature biofilm by 99% with a minimum inhibitory concentration value of 62.5 mu g/mL with significant reduction of EPS. These characteristics allow the use of the immobilized Arg-Trp rich AMP as a promising antimicrobial agent against microbial biofilms, present in water distribution systems. |
| Keyword | Antimicrobial peptides Arginine-tryptophan-rich dodecapeptides Pseudomonas aeruginosa Biofilms Water distribution systems |
| DOI | 10.1016/j.jhazmat.2021.128035 |
| Language | 英语 |
| WOS Keyword | PSEUDOMONAS-AERUGINOSA ; ANTIMICROBIAL PEPTIDES ; ANTIBACTERIAL ACTIVITY ; SILVER ; METAL ; NANOPARTICLES ; COMPOSITE ; CARBON ; CELLS |
| Funding Project | Applied Science and Technology Research and Development Special Foundation of Guangdong Province[2016B090930004] ; China Postdoctoral Science Foundation's 65th Batch of General Aid[2019M652822] |
| WOS Research Area | Engineering ; Environmental Sciences & Ecology |
| WOS Subject | Engineering, Environmental ; Environmental Sciences |
| Funding Organization | Applied Science and Technology Research and Development Special Foundation of Guangdong Province ; China Postdoctoral Science Foundation's 65th Batch of General Aid |
| WOS ID | WOS:000752476800002 |
| Publisher | ELSEVIER |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/51981 |
| Collection | 中国科学院过程工程研究所 |
| Corresponding Author | Hao, Zhifeng; Xing, Jianmin |
| Affiliation | 1.Chinese Acad Sci, CAS Key Lab Green Proc & Engn, Inst Proc Engn, Beijing 100190, Peoples R China 2.Chinese Acad Sci, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 3.Guangdong Univ Technol, Sch Chem Engn & Light Ind, Guangdong Prov Key Lab Plant Resources Biorefiner, Guangzhou 510006, Peoples R China 4.Univ Duisburg Essen, Aquat Microbiol, Environm Microbiol & Biotechnol, D-4141 Essen, Germany 5.Egyptian Petr Res Inst, Petr Applicat Dept, Cairo 11727, Egypt 6.Egyptian Petr Res Inst, Proc Design & Dev Dept, Cairo 11727, Egypt 7.Univ Chinese Acad Sci, Coll Chem Engn, Beijing 100049, Peoples R China 8.Chem & Chem Engn Guangdong Lab, Shantou 515031, Peoples R China |
| Recommended Citation GB/T 7714 | Samak, Nadia A.,Selim, Mohamed S.,Hao, Zhifeng,et al. Immobilized arginine/tryptophan-rich cyclic dodecapeptide on reduced graphene oxide anchored with manganese dioxide for microbial biofilm eradication[J]. JOURNAL OF HAZARDOUS MATERIALS,2022,426:15. |
| APA | Samak, Nadia A.,Selim, Mohamed S.,Hao, Zhifeng,&Xing, Jianmin.(2022).Immobilized arginine/tryptophan-rich cyclic dodecapeptide on reduced graphene oxide anchored with manganese dioxide for microbial biofilm eradication.JOURNAL OF HAZARDOUS MATERIALS,426,15. |
| MLA | Samak, Nadia A.,et al."Immobilized arginine/tryptophan-rich cyclic dodecapeptide on reduced graphene oxide anchored with manganese dioxide for microbial biofilm eradication".JOURNAL OF HAZARDOUS MATERIALS 426(2022):15. |
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