CAS OpenIR
Effectively Converting Cane Molasses into 2,3-Butanediol Using Clostridium ljungdahlii by an Integrated Fermentation and Membrane Separation Process
Yang, Yuling1,2; Deng, Tingting3; Cao, Weifeng2,4; Shen, Fei2,4; Liu, Sijia1; Zhang, Jing1; Liang, Xinquan1; Wan, Yinhua2,4
2022-02-01
Source PublicationMOLECULES
Volume27Issue:3Pages:15
AbstractFirstly, 2,3-butanediol (2,3-BDO) is a chemical platform used in several applications. However, the pathogenic nature of its producers and the expensive feedstocks used limit its scale production. In this study, cane molasses was used for 2,3-BDO production by a nonpathogenic Clostridium ljungdahlii. It was found that cane molasses alone, without the addition of other ingredients, was favorable for use as the culture medium for 2,3-BDO production. Compared with the control (i.e., the modified DSMZ 879 medium), the differential genes are mainly involved in the pathways of carbohydrate metabolism, membrane transport, and amino acid metabolism in the case of the cane molasses alone. However, when cane molasses alone was used, cell growth was significantly inhibited by KCl in cane molasses. Similarly, a high concentration of sugars (i.e., above 35 g/L) can inhibit cell growth and 2,3-BDO production. More seriously, 2,3-BDO production was inhibited by itself. As a result, cane molasses alone with an initial 35 g/L total sugars was suitable for 2,3-BDO production in batch culture. Finally, an integrated fermentation and membrane separation process was developed to maintain high 2,3-BDO productivity of 0.46 g center dot L-1 center dot h(-1). Meanwhile, the varied fouling mechanism indicated that the fermentation properties changed significantly, especially for the cell properties. Therefore, the integrated fermentation and membrane separation process was favorable for 2,3-BDO production by C. ljungdahlii using cane molasses.
Keyword2 3-butanediol Clostridium ljungdahlii cane molasses membrane separation
DOI10.3390/molecules27030954
Language英语
WOS KeywordACTINOBACILLUS-SUCCINOGENES ; AUREOBASIDIUM-PULLULANS ; SUCCINIC ACID ; KLEBSIELLA ; GLYCEROL ; ULTRAFILTRATION ; ENTEROBACTER ; DECOLORATION ; MECHANISMS ; ACETOIN
Funding ProjectBeijing Natural Science Foundation, China[5182025] ; National Natural Science Foundation of China, China[21406240] ; National High Technology Research and Development Program of China[2015AA021002] ; National High Technology Research and Development Program of China[2014AA021005]
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
Funding OrganizationBeijing Natural Science Foundation, China ; National Natural Science Foundation of China, China ; National High Technology Research and Development Program of China
WOS IDWOS:000759163500001
PublisherMDPI
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/52017
Collection中国科学院过程工程研究所
Corresponding AuthorCao, Weifeng; Liang, Xinquan
Affiliation1.Guangxi Univ, Coll Light Ind & Food Engn, Dept Sugar Engn, Nanning 530004, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
3.Chinese Acad Inspect & Quarantine, Agro Prod Safety Res Ctr, Beijing 100123, Peoples R China
4.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Yang, Yuling,Deng, Tingting,Cao, Weifeng,et al. Effectively Converting Cane Molasses into 2,3-Butanediol Using Clostridium ljungdahlii by an Integrated Fermentation and Membrane Separation Process[J]. MOLECULES,2022,27(3):15.
APA Yang, Yuling.,Deng, Tingting.,Cao, Weifeng.,Shen, Fei.,Liu, Sijia.,...&Wan, Yinhua.(2022).Effectively Converting Cane Molasses into 2,3-Butanediol Using Clostridium ljungdahlii by an Integrated Fermentation and Membrane Separation Process.MOLECULES,27(3),15.
MLA Yang, Yuling,et al."Effectively Converting Cane Molasses into 2,3-Butanediol Using Clostridium ljungdahlii by an Integrated Fermentation and Membrane Separation Process".MOLECULES 27.3(2022):15.
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