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Applications of Calcium-Based Nanomaterials in Osteoporosis Treatment
Deng, Yuan1; Wei, Wei2; Tang, Peifu1
2022-01-26
Source PublicationACS BIOMATERIALS SCIENCE & ENGINEERING
ISSN2373-9878
Pages20
AbstractWith rapidly aging populations worldwide, osteoporosis has become a serious global public health problem. Caused by disordered systemic bone remodeling, osteoporosis manifests as progressive loss of bone mass and microarchitectural deterioration of bone tissue, increasing the risk of fractures and eventually leading to osteoporotic fragility fractures. As fracture risk increases, antiosteoporosis treatments transition from nonpharmacological management to pharmacological intervention, and finally to the treatment of fragility fractures. Calcium-based nanomaterials (CBNMs) have unique advantages in osteoporosis treatment because of several characteristics including similarity to natural bone, excellent biocompatibility, easy preparation and functionalization, low pH-responsive disaggregation, and inherent proosteogenic properties. By combining additional ingredients, CBNMs can play multiple roles to construct antiosteoporotic biomaterials with different forms. This review covers recent advances in CBNMs for osteoporosis treatment. For ease of understanding, CBNMs for antiosteoporosis treatment can be classified as locally applied CBNMs, such as implant coatings and filling materials for osteoporotic bone regeneration, and systemically administered CBNMs for antiosteoporosis treatment. Locally applied CBNMs for osteoporotic bone regeneration develop faster than the systemically administered CBNMs, an important consideration given the serious outcomes of fragility fractures. Nevertheless, many innovations in construction strategies and preparation methods have been applied to build systemically administered CBNMs. Furthermore, with increasing interest in delaying osteoporosis progression and avoiding fragility fracture occurrence, research into systemic administration of CBNMs for antiosteoporosis treatment will have more development prospects. Deep understanding of the CBNM preparation process and optimizing CBNM properties will allow for increased application of CBNMs in osteoporosis treatments in the future.
Keywordcalcium nanomaterial osteoporosis local application systemic administration
DOI10.1021/acsbiomaterials.1c01306
Language英语
WOS KeywordMESOPOROUS BIOACTIVE GLASS ; NANOPARTICLE BASED FORMULATION ; VERTEBRAL FRACTURE RISK ; WALLED CARBON NANOTUBES ; BONE-MINERAL DENSITY ; IN-VITRO ; POSTMENOPAUSAL WOMEN ; PARATHYROID-HORMONE ; DRUG-DELIVERY ; OSTEOCLAST DIFFERENTIATION
Funding ProjectOpen Foundation of the Institute of Process Engineering, Chinese Academy of Sciences[2020KF-03]
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, Biomaterials
Funding OrganizationOpen Foundation of the Institute of Process Engineering, Chinese Academy of Sciences
WOS IDWOS:000758020600001
PublisherAMER CHEMICAL SOC
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/52117
Collection中国科学院过程工程研究所
Corresponding AuthorWei, Wei; Tang, Peifu
Affiliation1.Gen Hosp Chinese PLA, Med Ctr 4, Dept Orthoped, Beijing 100000, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Deng, Yuan,Wei, Wei,Tang, Peifu. Applications of Calcium-Based Nanomaterials in Osteoporosis Treatment[J]. ACS BIOMATERIALS SCIENCE & ENGINEERING,2022:20.
APA Deng, Yuan,Wei, Wei,&Tang, Peifu.(2022).Applications of Calcium-Based Nanomaterials in Osteoporosis Treatment.ACS BIOMATERIALS SCIENCE & ENGINEERING,20.
MLA Deng, Yuan,et al."Applications of Calcium-Based Nanomaterials in Osteoporosis Treatment".ACS BIOMATERIALS SCIENCE & ENGINEERING (2022):20.
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