CAS OpenIR
Ion Interference Therapy of Tumors Based on Inorganic Nanoparticles
Chi, Yongjie1,2; Sun, Peng1,3; Gao, Yuan1,4; Zhang, Jing1,2; Wang, Lianyan1,2
2022-02-01
Source PublicationBIOSENSORS-BASEL
Volume12Issue:2Pages:14
AbstractAs an essential substance for cell life activities, ions play an important role in controlling cell osmotic pressure balance, intracellular acid-base balance, signal transmission, biocatalysis and so on. The imbalance of ion homeostasis in cells will seriously affect the activities of cells, cause irreversible damage to cells or induce cell death. Therefore, artificially interfering with the ion homeostasis in tumor cells has become a new means to inhibit the proliferation of tumor cells. This treatment is called ion interference therapy (IIT). Although some molecular carriers of ions have been developed for intracellular ion delivery, inorganic nanoparticles are widely used in ion interference therapy because of their higher ion delivery ability and higher biocompatibility compared with molecular carriers. This article reviewed the recent development of IIT based on inorganic nanoparticles and summarized the advantages and disadvantages of this treatment and the challenges of future development, hoping to provide a reference for future research.
Keywordion interference therapy cancer ions inorganic nanoparticles
DOI10.3390/bios12020100
Language英语
WOS KeywordCALCIUM ; OVERLOAD
Funding ProjectNational Natural Science Foundation of China[81973262] ; National Natural Science Foundation of China[82011530138] ; National Natural Science Foundation of China[81970660]
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Instruments & Instrumentation
WOS SubjectChemistry, Analytical ; Nanoscience & Nanotechnology ; Instruments & Instrumentation
Funding OrganizationNational Natural Science Foundation of China
WOS IDWOS:000767769300001
PublisherMDPI
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/52199
Collection中国科学院过程工程研究所
Corresponding AuthorWang, Lianyan
Affiliation1.Chinese Acad Sci, Inst Proc Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100190, Peoples R China
3.Shenyang Agr Univ, Coll Biol Sci & Technol, Shenyang 110866, Peoples R China
4.Northeast Forestry Univ, Key Lab Forest Plant Ecol, Minist Educ, Coll Chem Chem Engn & Resource Utilizat, Harbin 150040, Peoples R China
Recommended Citation
GB/T 7714
Chi, Yongjie,Sun, Peng,Gao, Yuan,et al. Ion Interference Therapy of Tumors Based on Inorganic Nanoparticles[J]. BIOSENSORS-BASEL,2022,12(2):14.
APA Chi, Yongjie,Sun, Peng,Gao, Yuan,Zhang, Jing,&Wang, Lianyan.(2022).Ion Interference Therapy of Tumors Based on Inorganic Nanoparticles.BIOSENSORS-BASEL,12(2),14.
MLA Chi, Yongjie,et al."Ion Interference Therapy of Tumors Based on Inorganic Nanoparticles".BIOSENSORS-BASEL 12.2(2022):14.
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