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Cannabidiol/hydroxypropyl-beta-cyclodextrin inclusion complex: structure analysis, release behavior, permeability, and bioactivity under in vitro digestion
Li, Hang1,2; Zhao, Qingsheng1,2; Wang, Liwei1; Wang, Peidong1,2; Zhao, Bing1
2022-03-07
Source PublicationNEW JOURNAL OF CHEMISTRY
ISSN1144-0546
Volume46Issue:10Pages:4700-4709
AbstractCannabidiol (CBD), a natural phenolic compound, has many promising biological activities, but its use in food or other fields is restricted owing to inferior water solubility. So hydroxypropyl-beta-cyclodextrin (HP-beta-CD) was selected to form the inclusion complex (IC) of CBD to improve its solubility. The results showed CBD/HP-beta-CD IC was formed at a 1 : 1 molar ratio. The complexation was spontaneous, endothermic, and entropy-driven. The loading efficiency (LE) and complexation efficiency (CE) were 16.2% and 95.1%, respectively. NMR revealed CBD/HP-beta-CD IC was formed through incorporating the benzene ring of CBD into the HP-beta-CD cavity. The water solubility was greatly enhanced to 9.4 mu g mL(-1). About 80% of CBD molecules in the IC were released in simulated intestinal juice. The permeability, radical scavenging ability, and in vitro cytotoxicity of CBD were enhanced significantly after complexation. And the radical scavenging ability of digested IC was less potent compared with undigested IC but still stronger than that of CBD.
DOI10.1039/d1nj05998j
Language英语
WOS KeywordANTIOXIDANT ACTIVITY ; DRUG-DELIVERY ; CANNABIDIOL ; FORMULATION
Funding ProjectYunnan Hempmon Pharmaceutical Co.,Ltd.
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
Funding OrganizationYunnan Hempmon Pharmaceutical Co.,Ltd.
WOS IDWOS:000760907700001
PublisherROYAL SOC CHEMISTRY
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/52225
Collection中国科学院过程工程研究所
Corresponding AuthorZhao, Qingsheng; Zhao, Bing
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Li, Hang,Zhao, Qingsheng,Wang, Liwei,et al. Cannabidiol/hydroxypropyl-beta-cyclodextrin inclusion complex: structure analysis, release behavior, permeability, and bioactivity under in vitro digestion[J]. NEW JOURNAL OF CHEMISTRY,2022,46(10):4700-4709.
APA Li, Hang,Zhao, Qingsheng,Wang, Liwei,Wang, Peidong,&Zhao, Bing.(2022).Cannabidiol/hydroxypropyl-beta-cyclodextrin inclusion complex: structure analysis, release behavior, permeability, and bioactivity under in vitro digestion.NEW JOURNAL OF CHEMISTRY,46(10),4700-4709.
MLA Li, Hang,et al."Cannabidiol/hydroxypropyl-beta-cyclodextrin inclusion complex: structure analysis, release behavior, permeability, and bioactivity under in vitro digestion".NEW JOURNAL OF CHEMISTRY 46.10(2022):4700-4709.
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