CAS OpenIR
Amino-Acid-Encoded Supramolecular Photothermal Nanomedicine for Enhanced Cancer Therapy
Chang, Rui1,2; Zou, Qianli1,3; Zhao, Luyang1; Liu, Yamei1; Xing, Ruirui1,2; Yan, Xuehai1,2,4
2022-03-13
Source PublicationADVANCED MATERIALS
ISSN0935-9648
Pages9
AbstractPhotothermal nanomedicine based on self-assembly of biological components, with excellent biosafety and customized performance, is vital significance for precision cancer therapy. However, the programmable design of photothermal nanomedicine remains extremely challenging due to the vulnerability and variability of noncovalent interactions governing supramolecular self-assembly. Herein, it is reported that amino acid encoding is a facile and potent means to design and construct supramolecular photothermal nanodrugs with controlled therapeutic activities. It is found that the amount and type of amino acid dominates the assembled nanostructures, structural stability, energy-conversion pathway, and therapeutic mechanism of the resulting nanodrugs. Two optimized nanodrugs are endowed with robust structural integrity against disassembly along with high photothermal conversion efficiency, efficient cellular internalization, and enhanced tumor accumulation, which result in more efficient tumor ablation. This work demonstrates that design based on amino acid encoding offers an unprecedented opportunity for the construction of remarkable photoactive nanomedicines toward cancer diagnostics and therapeutics.
Keywordamino acid encoding cancer photothermal therapy noncovalent interactions self-assembly supramolecular nanomedicine
DOI10.1002/adma.202200139
Language英语
WOS KeywordPIGMENTS
Funding ProjectNational Science Fund for Distinguished Young Scholars of China[22025207] ; Innovation Research Community Science Fund of China[21821005] ; National Natural Science Foundation of China[22072154] ; National Natural Science Foundation of China[21977095] ; Key Research Program of Frontier Sciences of Chinese Academy of Sciences (CAS)[QYZDB-SSWJSC034] ; National Natural Science Foundation of Hebei Province[B2020103025]
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
Funding OrganizationNational Science Fund for Distinguished Young Scholars of China ; Innovation Research Community Science Fund of China ; National Natural Science Foundation of China ; Key Research Program of Frontier Sciences of Chinese Academy of Sciences (CAS) ; National Natural Science Foundation of Hebei Province
WOS IDWOS:000769611100001
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/52233
Collection中国科学院过程工程研究所
Corresponding AuthorXing, Ruirui; Yan, Xuehai
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China
3.Anhui Med Univ, Sch Pharm, Hefei 230032, Peoples R China
4.Chinese Acad Sci, Inst Proc Engn, Ctr Mesosci, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Chang, Rui,Zou, Qianli,Zhao, Luyang,et al. Amino-Acid-Encoded Supramolecular Photothermal Nanomedicine for Enhanced Cancer Therapy[J]. ADVANCED MATERIALS,2022:9.
APA Chang, Rui,Zou, Qianli,Zhao, Luyang,Liu, Yamei,Xing, Ruirui,&Yan, Xuehai.(2022).Amino-Acid-Encoded Supramolecular Photothermal Nanomedicine for Enhanced Cancer Therapy.ADVANCED MATERIALS,9.
MLA Chang, Rui,et al."Amino-Acid-Encoded Supramolecular Photothermal Nanomedicine for Enhanced Cancer Therapy".ADVANCED MATERIALS (2022):9.
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