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High molecular weight chitosan oligosaccharide exhibited antifungal activity by misleading cell wall organization via targeting PHR transglucosidases
Li, Ruilian1,2; Zhu, Limeng1,2; Liu, Dongdong2; Wang, Wenjing2,3; Zhang, Chen1,2; Jiao, Siming2; Wei, Jinhua1,2; Ren, Lishi2; Zhang, Yuchen2; Gou, Xun3; Yuan, Xianghua3; Du, Yuguang1,2; Wang, Zhuo A.1,2
2022-06-01
Source PublicationCARBOHYDRATE POLYMERS
ISSN0144-8617
Volume285Pages:14
AbstractThe fungal cell wall is an ideal target for the design of antifungal drugs. In this study we used an analog of cell wall polymer, a highly deacetylated high molecular-weight chitosan oligosaccharide (HCOS), to test its effect against pathogenic Candida strains. Results showed that HCOS was successfully incorporated into the dynamic cell wall organization process and exhibited an apparent antifungal activity against both plankton and mature fungal biofilm, by impairing the cell wall integrity. Unexpectedly, mechanistic studies suggested that HCOS exerts its activity by interfering with family members of PHR beta-(1,3)-glucanosyl transferases and affecting the connection and assembly of cell wall polysaccharides. Furthermore, HCOS showed great synergistic activity with different fungicides against Candida cells, especially those in biofilm. These findings indicated HCOS has a great potential as an antifungal drug or drug synergist and proposed a novel antifungal strategy with structure-specific oligosaccharides mimicking cell wall polysaccharide fragments.
KeywordCandida albicans Cell wall Biofilm Chitosan oligosaccharide PHR transglucosidases
DOI10.1016/j.carbpol.2022.119253
Language英语
WOS KeywordCANDIDA-ALBICANS ; IN-VITRO ; SACCHAROMYCES-CEREVISIAE ; PLASMA-MEMBRANE ; CHITIN ; VIRULENCE ; BIOSYNTHESIS ; INTEGRITY ; PROTEINS ; DEFENSE
Funding ProjectNational Key Research and Development Program of China[2018YFC0311300] ; National Natural Science Fund, China[31670809]
WOS Research AreaChemistry ; Polymer Science
WOS SubjectChemistry, Applied ; Chemistry, Organic ; Polymer Science
Funding OrganizationNational Key Research and Development Program of China ; National Natural Science Fund, China
WOS IDWOS:000761017700002
PublisherELSEVIER SCI LTD
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/52280
Collection中国科学院过程工程研究所
Corresponding AuthorDu, Yuguang; Wang, Zhuo A.
Affiliation1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
3.Sichuan Normal Univ, Coll Life Sci, Chengdu 610101, Peoples R China
Recommended Citation
GB/T 7714
Li, Ruilian,Zhu, Limeng,Liu, Dongdong,et al. High molecular weight chitosan oligosaccharide exhibited antifungal activity by misleading cell wall organization via targeting PHR transglucosidases[J]. CARBOHYDRATE POLYMERS,2022,285:14.
APA Li, Ruilian.,Zhu, Limeng.,Liu, Dongdong.,Wang, Wenjing.,Zhang, Chen.,...&Wang, Zhuo A..(2022).High molecular weight chitosan oligosaccharide exhibited antifungal activity by misleading cell wall organization via targeting PHR transglucosidases.CARBOHYDRATE POLYMERS,285,14.
MLA Li, Ruilian,et al."High molecular weight chitosan oligosaccharide exhibited antifungal activity by misleading cell wall organization via targeting PHR transglucosidases".CARBOHYDRATE POLYMERS 285(2022):14.
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