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Inhibition of amyloid-beta protein fibrillization upon interaction with polyoxometalates nanoclusters
Zhou, Yawen2; Zheng, Li1; Han, Fu2; Zhang, Guangjin1; Mac, Ying3; Yao, Jiannian3; Keita, Bineta4; de Oliveira, Pedro4; Nadjo, Louis4; Zhang, GJ
2011-02-05
Source PublicationCOLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
ISSN0927-7757
Volume375Issue:1-3Pages:97-101
AbstractIn this paper, two representative polyoxometalates (POMs), the wheel-shaped Preyssler anion INaP(5)W(30)O(110)](14-) (P5W30) and the Keggin-type anion [H(2)W(12)O(40)](6-) (H2W12) are shown to interact with A beta 1-40 and to inhibit its fibrillization. Circular Dichroism (CD) shows that addition of both POMs dramatically altered the evolution towards the final beta-sheet secondary structure. Atomic force microscopy (AFM) imaging and dynamic light scattering (DLS) experiments converge to indicate very different shapes and dimensions for the complexes formed in the absence and in the presence of the POMs. Finally, isothermal titration calorimetry (ITC) showed that both POMs showed a purely exothermic (Delta H < 0) interaction process. (C) 2010 Elsevier B.V. All rights reserved.
KeywordPolyoxometalates Nanocluster Beta-amyloid Inhibition Molecular Interaction
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
DOI10.1016/j.colsurfa.2010.11.068
Indexed BySCI
Language英语
WOS KeywordHUMAN SERUM-ALBUMIN ; ALZHEIMERS-DISEASE ; AGGREGATION ; COMPLEXES
WOS Research AreaChemistry
WOS SubjectChemistry, Physical
WOS IDWOS:000287285500013
Citation statistics
Cited Times:17[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.ipe.ac.cn/handle/122111/5261
Collection湿法冶金清洁生产技术国家工程实验室
Corresponding AuthorZhang, GJ
Affiliation1.Chinese Acad Sci, Key Lab Green Proc Engn, Inst Proc Engn, Beijing 100190, Peoples R China
2.Beijing Technol & Business Univ, Beijing 100048, Peoples R China
3.Chinese Acad Sci, Beijing Natl Lab Mol Sci BNLMS, Inst Chem, Beijing 100190, Peoples R China
4.Univ Paris 11, CNRS, UMR 8000, Lab Chim Phys,Grp Electrochim & Photoelectrochim, F-91405 Orsay, France
Recommended Citation
GB/T 7714
Zhou, Yawen,Zheng, Li,Han, Fu,et al. Inhibition of amyloid-beta protein fibrillization upon interaction with polyoxometalates nanoclusters[J]. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,2011,375(1-3):97-101.
APA Zhou, Yawen.,Zheng, Li.,Han, Fu.,Zhang, Guangjin.,Mac, Ying.,...&Zhang, GJ.(2011).Inhibition of amyloid-beta protein fibrillization upon interaction with polyoxometalates nanoclusters.COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,375(1-3),97-101.
MLA Zhou, Yawen,et al."Inhibition of amyloid-beta protein fibrillization upon interaction with polyoxometalates nanoclusters".COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 375.1-3(2011):97-101.
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