CAS OpenIR
Engineering mannosylated pickering emulsions for the targeted delivery of multicomponent vaccines
Du, Yiqun1,2; Song, Tiantian1,3; Wu, Jie1,3; Gao, Xiao-Dong4; Ma, Guanghui1,3; Liu, Yuchen2; Xia, Yufei1,3
2022
Source PublicationBIOMATERIALS
ISSN0142-9612
Volume280Pages:11
AbstractWhile research on cancer vaccines has made great strides in the field of immunotherapy, the targeted delivery of multiple effective components (rational-tailored antigens and adjuvants) remains a challenge. Here, we utilized the unique hierarchical structures of Pickering emulsions (particles, oil core, and water-oil interface) to develop mannosylated (M) Pickering emulsions (PE) that target antigen presenting cells and synergistically deliver antigenic peptides and the TLR9 agonist CpG (C) as an enhanced cancer vaccine (MPE-C). We chemically linked mannose residues to PLGA/PLAG-PEG nanoparticles and produced a dense array of mannose on the nano patterned surface of Pickering emulsions, allowing for increased cellular targeting. Together with the inherent deformability of the oily core, MPE-C increased the droplet-cellular contact area and provoked the cellular recognition of mannose and CpG for enhanced immune activation. We found that MPE-C attracted a large number of APCs to the local site of administration, evidently increasing cellular uptake and activation. Additionally, we observed increased antigen-specific cellular immune responses, with potent anti-tumor effects against both E.G7-OVA and B16-MUCI tumors. Furthermore, MPE-C combined with PD-1 antibodies produced a significant tumor regression, resulting in synergistic increases in anti-tumor effects. Thus, through the strategic loading of mannose, antigens, and CpG, Pickering emulsions could serve as a targeted delivery platform for enhanced multicomponent cancer vaccines.
KeywordCancer vaccine Pickering emulsion Targeted vaccine delivery system Mannose CpG
DOI10.1016/j.biomaterials.2021.121313
Language英语
WOS KeywordLYMPH-NODE ; CANCER ; NANOVACCINE ; ADJUVANTS ; INNATE
Funding ProjectFoundation for CAS Project for Young Scientists in Basic Research[YSBR-010] ; Pilot Project of Chinese Academy of Sciences[XDB29040303] ; China Postdoctoral Science Foundation[2020TQ0205] ; China Postdoctoral Science Foundation[2020M682906] ; "From 0 to 1" Original Innovation Project of Basic Frontier Scientific Research Program of Chinese Academy of Sciences[ZDBS-LY-SLH040] ; Project of National Natural Science Foundation of China[21908229] ; Project of National Natural Science Foundation of China[81773257] ; Project of National Natural Science Foundation of China[81972867] ; Innovative Research Groups of the National Natural Science Foundation of China[21821005] ; Beijing Nova Program of Beijing Municipal Science & Technology Commission[Z201100006820139] ; Project of National Key R&D Program of China[2021YFA0911600] ; Project of Natural Science Foundation of Guangdong Province[2018B030306023] ; Shenzhen Municipal Science and Technology Innovation Council[RCYX20200714114701035] ; Shenzhen Municipal Science and Technology Innovation Council[JCYJ20180507184642475]
WOS Research AreaEngineering ; Materials Science
WOS SubjectEngineering, Biomedical ; Materials Science, Biomaterials
Funding OrganizationFoundation for CAS Project for Young Scientists in Basic Research ; Pilot Project of Chinese Academy of Sciences ; China Postdoctoral Science Foundation ; "From 0 to 1" Original Innovation Project of Basic Frontier Scientific Research Program of Chinese Academy of Sciences ; Project of National Natural Science Foundation of China ; Innovative Research Groups of the National Natural Science Foundation of China ; Beijing Nova Program of Beijing Municipal Science & Technology Commission ; Project of National Key R&D Program of China ; Project of Natural Science Foundation of Guangdong Province ; Shenzhen Municipal Science and Technology Innovation Council
WOS IDWOS:000783915900002
PublisherELSEVIER SCI LTD
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/52714
Collection中国科学院过程工程研究所
Corresponding AuthorLiu, Yuchen; Xia, Yufei
Affiliation1.Inst Proc Engn, Chinese Acad Sci, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.First Affiliated Hosp Shenzhen Univ, Shenzhen Peoples Hosp 2, Shenzhen Inst Translat Med, Hlth Sci Ctr, Shenzhen 518035, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100190, Peoples R China
4.Jiangnan Univ, Sch Biotechnol, Key Lab Carbohydrate Chem & Biotechnol, Minist Educ, Wuxi 214122, Peoples R China
Recommended Citation
GB/T 7714
Du, Yiqun,Song, Tiantian,Wu, Jie,et al. Engineering mannosylated pickering emulsions for the targeted delivery of multicomponent vaccines[J]. BIOMATERIALS,2022,280:11.
APA Du, Yiqun.,Song, Tiantian.,Wu, Jie.,Gao, Xiao-Dong.,Ma, Guanghui.,...&Xia, Yufei.(2022).Engineering mannosylated pickering emulsions for the targeted delivery of multicomponent vaccines.BIOMATERIALS,280,11.
MLA Du, Yiqun,et al."Engineering mannosylated pickering emulsions for the targeted delivery of multicomponent vaccines".BIOMATERIALS 280(2022):11.
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