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| Promotion of Carbon Dioxide Biofixation through Metabolic and Enzyme Engineering | |
| Pu, Xin1,2; Han, Yejun1,2 | |
| 2022-04-01 | |
| Source Publication | CATALYSTS
 |
| Volume | 12Issue:4Pages:17 |
| Abstract | Carbon dioxide is a major greenhouse gas, and its fixation and transformation are receiving increasing attention. Biofixation of CO2 is an eco-friendly and efficient way to reduce CO2, and six natural CO2 fixation pathways have been identified in microorganisms and plants. In this review, the six pathways along with the most recent identified variant pathway were firstly comparatively characterized. The key metabolic process and enzymes of the CO2 fixation pathways were also summarized. Next, the enzymes of Rubiscos, biotin-dependent carboxylases, CO dehydrogenase/acetyl-CoA synthase, and 2-oxoacid:ferredoxin oxidoreductases, for transforming inorganic carbon (CO2, CO, and bicarbonate) to organic chemicals, were specially analyzed. Then, the factors including enzyme properties, CO2 concentrating, energy, and reducing power requirements that affect the efficiency of CO2 fixation were discussed. Recent progress in improving CO2 fixation through enzyme and metabolic engineering was then summarized. The artificial CO2 fixation pathways with thermodynamical and/or energetical advantages or benefits and their applications in biosynthesis were included as well. The challenges and prospects of CO2 biofixation and conversion are discussed. |
| Keyword | carbon dioxide biofixation carboxylases enzyme engineering metabolic engineering artificial carbon fixation pathway |
| DOI | 10.3390/catal12040399 |
| Language | 英语 |
| WOS Keyword | 2-OXOACID FERREDOXIN OXIDOREDUCTASE ; PROPIONYL-COA CARBOXYLASE ; WOOD-LJUNGDAHL PATHWAY ; REDUCTIVE CARBOXYLATION ; ISOCITRATE DEHYDROGENASES ; CHLOROFLEXUS-AURANTIACUS ; DIRECTED EVOLUTION ; TCA CYCLE ; FIXATION ; RUBISCO |
| Funding Project | National Key Research and Development Program of China[2021YFC2101603] ; National Natural Science Foundation of China[32170093] |
| WOS Research Area | Chemistry |
| WOS Subject | Chemistry, Physical |
| Funding Organization | National Key Research and Development Program of China ; National Natural Science Foundation of China |
| WOS ID | WOS:000786063200001 |
| Publisher | MDPI |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/52753 |
| Collection | 中国科学院过程工程研究所 |
| Corresponding Author | Han, Yejun |
| Affiliation | 1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China |
| Recommended Citation GB/T 7714 | Pu, Xin,Han, Yejun. Promotion of Carbon Dioxide Biofixation through Metabolic and Enzyme Engineering[J]. CATALYSTS,2022,12(4):17. |
| APA | Pu, Xin,&Han, Yejun.(2022).Promotion of Carbon Dioxide Biofixation through Metabolic and Enzyme Engineering.CATALYSTS,12(4),17. |
| MLA | Pu, Xin,et al."Promotion of Carbon Dioxide Biofixation through Metabolic and Enzyme Engineering".CATALYSTS 12.4(2022):17. |
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