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Hybrid hydrogel microspheres loading single-hole hollow imprinted particles for fast and selective uptake of 2'& nbsp;-deoxyadenosine

Zhou, Mengdie1; Wang, Pan1; Song, Yulin1; Li, Hao1; Luo, Jianquan2; Pan, Jianming1,2
2022-04-15
Source PublicationSEPARATION AND PURIFICATION TECHNOLOGY
ISSN1383-5866
Volume287Pages:11
AbstractHydrogel microspheres encapsulating molecularly imprinted polymers (MIPs) are promising hybrid sorbents, due to several advantages of high selectivity, fast mass transfer efficiency, and simple collection. Thus, Janus single hole hollow nanoparticles (J-HNPs) with the size of 550 +/-& nbsp; 70 nm were firstly designed by anisotropic emulsion template, and then MIPs were grafted onto their inner surface through electron transfer atom transfer radical polymerization (ARGET ATRP). Then as-prepared J-HNPs-MIPs were loaded into hydrogel microspheres via polymerizable water-in-oil (W/O) emulsion droplets combining gelatin methacryloyl (GMA) as monomers, and then obtained J-HNPs-MIPs@Gel with the mean diameter of 2.0 mu m was applied for effective and selective separation of 2'-deoxyadenosine (dA). Fast adsorption equilibrium of J-HNPs-MIPs@Gel for dA can be achieved within 40 min, thanks to the hydrogel matrix and single-hole hollow structure for enhancing diffusion. The maximum multi-layer adsorption capacity calculated according to the Freundlich model was 10.31 mu mol g(-1) at 298 K. The specific memory to the size, shape and functional groups of dA endowed excellent recognition ability, and 88% of the initial capacity after four consecutive adsorption-desorption cycles was maintained. In addition, J-HNPs-MIPs@Gel was expected to show great potential for the selective enrichment and analysis of target dA molecule in complex biological samples.
KeywordSingle-hole hollow particles Molecularly imprinted polymers (MIPs) Gelatin methacryloyl (GMA) Selective dA adsorption Hybrid hydrogel microspheres
DOI10.1016/j.seppur.2022.120472
Language英语
WOS KeywordMAGNETIC NANOPARTICLES ; CARBON NANOTUBES ; FAST SEPARATION ; ADSORPTION ; SURFACE ; RECOGNITION ; POLYMER ; SULFONAMIDES ; NANOBOTTLES ; TEMPLATE
Funding ProjectNational Natural Science Foundation of China[22078132] ; National Natural Science Foundation of China[21822807] ; National Natural Science Foundation of China[21878026] ; Open Research Fund Program of Beijing Key Lab of Plant Resource Research and Development[PRRD-2019-ZD1] ; State Key Laboratory Foundation of Efficient Utilization for Low Grade Phosphate Rock and Its Associated Resources[WFKF2020-03] ; Open Funding Project of the National Key Laboratory of Biochemical Engineering
WOS Research AreaEngineering
WOS SubjectEngineering, Chemical
Funding OrganizationNational Natural Science Foundation of China ; Open Research Fund Program of Beijing Key Lab of Plant Resource Research and Development ; State Key Laboratory Foundation of Efficient Utilization for Low Grade Phosphate Rock and Its Associated Resources ; Open Funding Project of the National Key Laboratory of Biochemical Engineering
WOS IDWOS:000781625200001
PublisherELSEVIER
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Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/52805
Collection中国科学院过程工程研究所
Corresponding AuthorLi, Hao; Luo, Jianquan; Pan, Jianming
Affiliation1.Jiangsu Univ, Sch Chem & Chem Engn, Zhenjiang 212013, Jiangsu, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 10090, Peoples R China
Recommended Citation
GB/T 7714
Zhou, Mengdie,Wang, Pan,Song, Yulin,et al.

Hybrid hydrogel microspheres loading single-hole hollow imprinted particles for fast and selective uptake of 2'& nbsp;-deoxyadenosine

[J]. SEPARATION AND PURIFICATION TECHNOLOGY,2022,287:11.
APA Zhou, Mengdie,Wang, Pan,Song, Yulin,Li, Hao,Luo, Jianquan,&Pan, Jianming.(2022).

Hybrid hydrogel microspheres loading single-hole hollow imprinted particles for fast and selective uptake of 2'& nbsp;-deoxyadenosine

.SEPARATION AND PURIFICATION TECHNOLOGY,287,11.
MLA Zhou, Mengdie,et al."

Hybrid hydrogel microspheres loading single-hole hollow imprinted particles for fast and selective uptake of 2'& nbsp;-deoxyadenosine

".SEPARATION AND PURIFICATION TECHNOLOGY 287(2022):11.
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