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Ni Nanoparticles Embedded Ti3C2Tx-MXene Nanoarchitectures for Electrochemical Sensing of Methylmalonic Acid
Kumar, Jai1; Soomro, Razium Ali1; Neiber, Rana R.2,3; Ahmed, Nazeer4; Medany, Shymaa S.5; Albaqami, Munirah D.6; Nafady, Ayman6
2022-04-01
Source PublicationBIOSENSORS-BASEL
Volume12Issue:4Pages:11
AbstractMXenes-Ti3C2Tx, based on their versatile surface characteristics, has rapidly advanced as an interactive substrate to develop electrochemical sensors for clinical applications. Herein, Ni embedded Ti3C2Tx, (MX-Ni) composites were prepared using a self-assembly approach where Ti3C2Tx, sheets served as an interactive conductive substrate as well as a protective layer to nickel nanoparticles (Ni NPs), preventing their surface oxidation and aggregation. The composite displayed a cluster-like morphology with an intimate interfacial arrangement between Ni, Ti3C2Tx and Ti3C2Tx-derived TiO2. The configuration of MX-Ni into an electrochemical sensor realized a robust cathodic reduction current against methylmalonic acid (MMA), a biomarker to vitamin B12 deficiency. The synergism of Ni NPs strong redox characteristics with conductive Ti3C2Tx enabled sensitive signal output in wide detection ranges of 0.001 to 0.003 mu M and 0.0035 to 0.017 mu M and a detection sensitivity down to 0.12 mu M of MMA. Importantly, the sensor demonstrated high signal reproducibility and excellent operational capabilities for MMA in a complex biological matrix such as human urine samples.
KeywordMXenes methylmalonic acid Ni NPs electrochemical sensors vitamin B12
DOI10.3390/bios12040231
Language英语
WOS KeywordMXENE
Funding ProjectKing Saud University, Riyadh, Saudi Arabia[RSP-2022/79]
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Instruments & Instrumentation
WOS SubjectChemistry, Analytical ; Nanoscience & Nanotechnology ; Instruments & Instrumentation
Funding OrganizationKing Saud University, Riyadh, Saudi Arabia
WOS IDWOS:000785183700001
PublisherMDPI
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/52865
Collection中国科学院过程工程研究所
Corresponding AuthorSoomro, Razium Ali
Affiliation1.Beijing Univ Chem Technol, State Key Lab Organ Inorgan Composites, Beijing Key Lab Electrochem Proc & Technol Mat, Beijing 100029, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, Beijing Key Lab Ion Liquids Clean Proc, CAS Key Lab Green Proc & Engn, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, Coll Chem Engn, 19A Yuquan Rd, Beijing 100049, Peoples R China
4.Sapienza Univ Rome, Res Ctr Nanotechnol Appl Engn Sapienza CNIS, Ple Aldo Moro 5, I-00185 Rome, Italy
5.Cairo Univ, Fac Sci, Dept Chem, Giza 12613, Egypt
6.King Saud Univ, Coll Sci, Dept Chem, POB 2455, Riyadh 11451, Saudi Arabia
Recommended Citation
GB/T 7714
Kumar, Jai,Soomro, Razium Ali,Neiber, Rana R.,et al. Ni Nanoparticles Embedded Ti3C2Tx-MXene Nanoarchitectures for Electrochemical Sensing of Methylmalonic Acid[J]. BIOSENSORS-BASEL,2022,12(4):11.
APA Kumar, Jai.,Soomro, Razium Ali.,Neiber, Rana R..,Ahmed, Nazeer.,Medany, Shymaa S..,...&Nafady, Ayman.(2022).Ni Nanoparticles Embedded Ti3C2Tx-MXene Nanoarchitectures for Electrochemical Sensing of Methylmalonic Acid.BIOSENSORS-BASEL,12(4),11.
MLA Kumar, Jai,et al."Ni Nanoparticles Embedded Ti3C2Tx-MXene Nanoarchitectures for Electrochemical Sensing of Methylmalonic Acid".BIOSENSORS-BASEL 12.4(2022):11.
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