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Factors influencing artemisinin production from shoot cultures of Artemisia annua L
Alternative TitleWorld J. Microbiol. Biotechnol.
Liu, C. Z.; Guo, C.; Wang, Y. C.; Fan, O. Y.
2003
Source PublicationWorld Journal of Microbiology & Biotechnology
Issue5Pages:535-538
AbstractArtemisinin, an anti-malarial drug isolated from the annual wormwood Artemisia annua L., has a marked activity against chloroquine-resistant and chloroquine-sensitive strains of Plasmodium falciparum, and is useful in treatment of cerebral malaria. Shoot cultures of Artemisia annua L. were established on Murashige and Skoog basal medium which contained (per litre) 30 g sucrose, 0.5 mg 6-benzyladenine and 0.05 mg naphthaleneacetic acid. Using an optimized combination of sucrose (30 g/l), nitrate (45 mM), inorganic phosphate (200 mg/l), gibberellic acid (7 mg/l) and the ratio of NH4+-N to NO3--N of 1:3, artemisinin production reached 26.7 mg/l after 30 days. This procedure provides a potential alternative for production of artemisinin from in vitro tissue cultures.
KeywordArtemisinin Biosynthesis Artemisia Annua L. Biomass Plant-based Valuable Metabolite Production Shoot Culture Hairy Root Cultures Qinghaosu Artemisinin Suspension-cultures Antimalarial Drug Ginseng Saponin Tissue-cultures Improved Growth Panax-ginseng Sucrose Light
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Indexed BySCI
Language英语
Document Type期刊论文
Version出版稿
Identifierhttp://ir.ipe.ac.cn/handle/122111/5290
Collection研究所(批量导入)
Recommended Citation
GB/T 7714
Liu, C. Z.,Guo, C.,Wang, Y. C.,et al. Factors influencing artemisinin production from shoot cultures of Artemisia annua L[J]. World Journal of Microbiology & Biotechnology,2003(5):535-538.
APA Liu, C. Z.,Guo, C.,Wang, Y. C.,&Fan, O. Y..(2003).Factors influencing artemisinin production from shoot cultures of Artemisia annua L.World Journal of Microbiology & Biotechnology(5),535-538.
MLA Liu, C. Z.,et al."Factors influencing artemisinin production from shoot cultures of Artemisia annua L".World Journal of Microbiology & Biotechnology .5(2003):535-538.
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