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Investigation of pH sensitivity of poly(acrylic acid-co-acrylamide) hydrogel
Alternative TitlePolym. Int.
Zhou, XJ; Weng, LH; Chen, Q; Zhang, JM; Shen, DY; Li, ZC; Shao, MJ; Xu, J
2003-07-01
Source PublicationPOLYMER INTERNATIONAL
ISSN0959-8103
Volume52Issue:7Pages:1153-1157
AbstractIt was found that the upper critical solution temperature (UCST) of poly(acrylic acid-co-acrylamide) hydrogel decreases with increase in pH. The UCST of samples equilibrated in a buffer at pH 2.5 was 33.7 degreesC, whereas it shifted to below 0 degreesC when swollen in buffers above pH 10. FT-IR showed that COOH group of acrylic acid ionized gradually in alkaline media. The morphology change of the hydrogel swollen in different buffers was studied by environmental scanning electron microscopy (ESEM). ESEM images showed that the pore size of the sample increased with increase in pH, and in strongly basic media the three-dimensional network was replaced by a `sausage-like' or `desert-like' structure. A study of the pH-dependent release of cefazolin sodium was also carried out. (C) 2003 Society of Chemical Industry.; It was found that the upper critical solution temperature (UCST) of poly(acrylic acid-co-acrylamide) hydrogel decreases with increase in pH. The UCST of samples equilibrated in a buffer at pH 2.5 was 33.7 degreesC, whereas it shifted to below 0 degreesC when swollen in buffers above pH 10. FT-IR showed that COOH group of acrylic acid ionized gradually in alkaline media. The morphology change of the hydrogel swollen in different buffers was studied by environmental scanning electron microscopy (ESEM). ESEM images showed that the pore size of the sample increased with increase in pH, and in strongly basic media the three-dimensional network was replaced by a `sausage-like' or `desert-like' structure. A study of the pH-dependent release of cefazolin sodium was also carried out. (C) 2003 Society of Chemical Industry.
KeywordPh Sensitivity Hydrogel Upper Critical Solution Temperature Poly(Acrylic Acid-co-acrylamide)
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
DOI10.1002/pi.1207
URL查看原文
Indexed BySCI
Language英语
WOS KeywordACID-CO-2-HYDROXYETHYL METHACRYLATE) HYDROGELS ; INTERPENETRATING POLYMER NETWORKS ; IONIZABLE DRUGS ; ACID) ; RELEASE ; TEMPERATURE ; TRANSPORT ; PROTEINS ; DELIVERY
WOS Research AreaPolymer Science
WOS SubjectPolymer Science
WOS IDWOS:000183923600015
Citation statistics
Cited Times:34[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.ipe.ac.cn/handle/122111/5304
Collection研究所(批量导入)
Affiliation1.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, State Key Lab Polymer Phys & Chem, Beijing 100080, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, Multiphase React Lab, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Zhou, XJ,Weng, LH,Chen, Q,et al. Investigation of pH sensitivity of poly(acrylic acid-co-acrylamide) hydrogel[J]. POLYMER INTERNATIONAL,2003,52(7):1153-1157.
APA Zhou, XJ.,Weng, LH.,Chen, Q.,Zhang, JM.,Shen, DY.,...&Xu, J.(2003).Investigation of pH sensitivity of poly(acrylic acid-co-acrylamide) hydrogel.POLYMER INTERNATIONAL,52(7),1153-1157.
MLA Zhou, XJ,et al."Investigation of pH sensitivity of poly(acrylic acid-co-acrylamide) hydrogel".POLYMER INTERNATIONAL 52.7(2003):1153-1157.
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