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Advances in oral peptide drug nanoparticles for diabetes mellitus treatment
Li, Yan1; Zhang, Wen1; Zhao, Ruichen2,3; Zhang, Xin2
2022-09-01
Source PublicationBIOACTIVE MATERIALS
Volume15Pages:392-408
AbstractPeptide drugs play an important role in diabetes mellitus treatment. Oral administration of peptide drugs is a promising strategy for diabetes mellitus because of its convenience and high patient compliance compared to parenteral administration routes. However, there are a series of formidable unfavorable conditions present in the gastrointestinal (GI) tract after oral administration, which result in the low oral bioavailability of these peptide drugs. To overcome these challenges, various nanoparticles (NPs) have been developed to improve the oral absorption of peptide drugs due to their unique in vivo properties and high design flexibility. This review discusses the unfavorable conditions present in the GI tract and provides the corresponding strategies to overcome these challenges. The review provides a comprehensive overview on the NPs that have been constructed for oral peptide drug delivery in diabetes mellitus treatment. Finally, we will discuss the rational application and give some suggestions that can be utilized for the development of oral peptide drug NPs. Our aim is to provide a systemic and comprehensive review of oral peptide drug NPs that can overcome the challenges in GI tract for efficient treatment of diabetes mellitus.
KeywordOral nanoparticles Peptide drugs Gastrointestinal tract Diabetes mellitus Oral bioavailability
DOI10.1016/j.bioactmat.2022.02.025
Language英语
WOS KeywordPANCREATIC BETA-CELL ; MESOPOROUS SILICA NANOPARTICLES ; INTESTINAL PERMEATION ENHANCERS ; SELF-ASSEMBLED NANOPARTICLES ; CHITOSAN NANOPARTICLES ; FUNCTIONALIZED NANOPARTICLES ; POLYMERIC NANOPARTICLES ; LOADED NANOPARTICLES ; SURFACE-CHEMISTRY ; DIFFUSION BARRIER
Funding ProjectNational Natural Science Foundation of China[32071391] ; National Natural Science Foundation of China[21905283] ; National Natural Science Foundation of China[31771095] ; National Natural Science Foundation of China[21875254] ; National Natural Science Foundation of China[52073287] ; National Natural Science Foundation of China[22075289] ; Fundamental Research Funds for the Central Universities[06500230] ; Beijing Nova Program[Z201100006820140]
WOS Research AreaEngineering ; Materials Science
WOS SubjectEngineering, Biomedical ; Materials Science, Biomaterials
Funding OrganizationNational Natural Science Foundation of China ; Fundamental Research Funds for the Central Universities ; Beijing Nova Program
WOS IDWOS:000789663900001
PublisherKEAI PUBLISHING LTD
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/53065
Collection中国科学院过程工程研究所
Corresponding AuthorLi, Yan; Zhang, Xin
Affiliation1.Univ Sci & Technol Beijing, Sch Chem & Biol Engn, Beijing 100083, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Li, Yan,Zhang, Wen,Zhao, Ruichen,et al. Advances in oral peptide drug nanoparticles for diabetes mellitus treatment[J]. BIOACTIVE MATERIALS,2022,15:392-408.
APA Li, Yan,Zhang, Wen,Zhao, Ruichen,&Zhang, Xin.(2022).Advances in oral peptide drug nanoparticles for diabetes mellitus treatment.BIOACTIVE MATERIALS,15,392-408.
MLA Li, Yan,et al."Advances in oral peptide drug nanoparticles for diabetes mellitus treatment".BIOACTIVE MATERIALS 15(2022):392-408.
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