Knowledge Management System Of Institute of process engineering,CAS
| Advances in oral peptide drug nanoparticles for diabetes mellitus treatment | |
| Li, Yan1; Zhang, Wen1; Zhao, Ruichen2,3; Zhang, Xin2 | |
| 2022-09-01 | |
| Source Publication | BIOACTIVE MATERIALS
 |
| Volume | 15Pages:392-408 |
| Abstract | Peptide drugs play an important role in diabetes mellitus treatment. Oral administration of peptide drugs is a promising strategy for diabetes mellitus because of its convenience and high patient compliance compared to parenteral administration routes. However, there are a series of formidable unfavorable conditions present in the gastrointestinal (GI) tract after oral administration, which result in the low oral bioavailability of these peptide drugs. To overcome these challenges, various nanoparticles (NPs) have been developed to improve the oral absorption of peptide drugs due to their unique in vivo properties and high design flexibility. This review discusses the unfavorable conditions present in the GI tract and provides the corresponding strategies to overcome these challenges. The review provides a comprehensive overview on the NPs that have been constructed for oral peptide drug delivery in diabetes mellitus treatment. Finally, we will discuss the rational application and give some suggestions that can be utilized for the development of oral peptide drug NPs. Our aim is to provide a systemic and comprehensive review of oral peptide drug NPs that can overcome the challenges in GI tract for efficient treatment of diabetes mellitus. |
| Keyword | Oral nanoparticles Peptide drugs Gastrointestinal tract Diabetes mellitus Oral bioavailability |
| DOI | 10.1016/j.bioactmat.2022.02.025 |
| Language | 英语 |
| WOS Keyword | PANCREATIC BETA-CELL ; MESOPOROUS SILICA NANOPARTICLES ; INTESTINAL PERMEATION ENHANCERS ; SELF-ASSEMBLED NANOPARTICLES ; CHITOSAN NANOPARTICLES ; FUNCTIONALIZED NANOPARTICLES ; POLYMERIC NANOPARTICLES ; LOADED NANOPARTICLES ; SURFACE-CHEMISTRY ; DIFFUSION BARRIER |
| Funding Project | National Natural Science Foundation of China[32071391] ; National Natural Science Foundation of China[21905283] ; National Natural Science Foundation of China[31771095] ; National Natural Science Foundation of China[21875254] ; National Natural Science Foundation of China[52073287] ; National Natural Science Foundation of China[22075289] ; Fundamental Research Funds for the Central Universities[06500230] ; Beijing Nova Program[Z201100006820140] |
| WOS Research Area | Engineering ; Materials Science |
| WOS Subject | Engineering, Biomedical ; Materials Science, Biomaterials |
| Funding Organization | National Natural Science Foundation of China ; Fundamental Research Funds for the Central Universities ; Beijing Nova Program |
| WOS ID | WOS:000789663900001 |
| Publisher | KEAI PUBLISHING LTD |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/53065 |
| Collection | 中国科学院过程工程研究所 |
| Corresponding Author | Li, Yan; Zhang, Xin |
| Affiliation | 1.Univ Sci & Technol Beijing, Sch Chem & Biol Engn, Beijing 100083, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China |
| Recommended Citation GB/T 7714 | Li, Yan,Zhang, Wen,Zhao, Ruichen,et al. Advances in oral peptide drug nanoparticles for diabetes mellitus treatment[J]. BIOACTIVE MATERIALS,2022,15:392-408. |
| APA | Li, Yan,Zhang, Wen,Zhao, Ruichen,&Zhang, Xin.(2022).Advances in oral peptide drug nanoparticles for diabetes mellitus treatment.BIOACTIVE MATERIALS,15,392-408. |
| MLA | Li, Yan,et al."Advances in oral peptide drug nanoparticles for diabetes mellitus treatment".BIOACTIVE MATERIALS 15(2022):392-408. |
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