CAS OpenIR
Acid-Sensitive Nanoparticles Based on Molybdenum Disulfide for Photothermal-Chemo Therapy br
Liu, Qin1; Song, Ping1; Zhang, Weiwei1; Wang, Zhenyu1; Yang, Kai2,3; Luo, Jianquan4; Zhu, Longbao1; Gui, Lin5; Tao, Yugui1; Ge, Fei1
2022-04-11
Source PublicationACS BIOMATERIALS SCIENCE & ENGINEERING
ISSN2373-9878
Volume8Issue:4Pages:1706-1716
AbstractThe combination of multiple treatments hasrecently been investigated for tumor treatment. In this study,molybdenum disulfide (MoS2) with excellent photothermalconversion performance was used as the core, and manganesedioxide (MnO2), which responds to the tumor microenvironment,was loaded on its surface by liquid deposition to form amesoporous core-shell structure. Then, the chemotherapeuticdrug Adriamycin (DOX) was loaded into the hole. To furtherenhance its water solubility and stability, the surface of MnO2wasmodified with mPEG-NH2to prepare the combined antitumornanocomposite MoS2@DOX/MnO2-PEG (MDMP). The resultsshowed that MDMP had a diameter of about 236 nm, itsphotothermal conversion efficiency was 33.7%, and the loading andrelease rates of DOX were 13 and 65%, respectively. Duringin vivoandin vitrostudies, MDMP showed excellent antitumor activity.Under the combined treatment, the tumor cell viability rate was only 11.8%. This nanocomposite exhibits considerable potential forchemo-photothermal combined antitumor therapy
Keywordmolybdenum disulfide (MoS2) nanoparticles manganese dioxide (MnO2) DOX photothermal-chemo antitumor therapy
DOI10.1021/acsbiomaterials.1c01390
Language英语
WOS KeywordTUMOR-MICROENVIRONMENT ; DRUG-DELIVERY ; NANO-PLATFORM ; MOS2 ; NANOSHEETS ; GRAPHENE ; MNO2
Funding ProjectNational natural science foundation of China[31671797] ; Anhui Nature Science Foundation[1808085QC85] ; Anhui Nature Science Foundation[2008085QH397] ; Anhui Provincial Higher Education Institutes[KJ2020a0375] ; Anhui Polytechnic University[xjky2020064] ; Natural Science Foundation of Anhui University[KJ2020A118] ; Youth Key Talents Program of Wannan Medical College ; Talents Program of Wannan Medical College[wyqnyx202005]
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, Biomaterials
Funding OrganizationNational natural science foundation of China ; Anhui Nature Science Foundation ; Anhui Provincial Higher Education Institutes ; Anhui Polytechnic University ; Natural Science Foundation of Anhui University ; Youth Key Talents Program of Wannan Medical College ; Talents Program of Wannan Medical College
WOS IDWOS:000789105600028
PublisherAMER CHEMICAL SOC
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/53084
Collection中国科学院过程工程研究所
Corresponding AuthorZhu, Longbao; Gui, Lin; Tao, Yugui; Ge, Fei
Affiliation1.Anhui Polytech Univ, Sch Biol & Food Engn, Wuhu 241000, Anhui, Peoples R China
2.Soochow Univ, Collaborat Innovat Ctr Radiat Med Jiangsu Higher, Sch Radiat Med & Protect, State Key Lab Radiat Med & Protect, Suzhou 215123, Jiangsu, Peoples R China
3.Soochow Univ, Collaborat Innovat Ctr Radiat Med Jiangsu Higher, Sch Radiol & Interdisciplinary Sci RAD X, Suzhou 215123, Jiangsu, Peoples R China
4.Univ Chinese Acad Sci, Inst Proc Engn, Beijing 100049, Peoples R China
5.Wannan Med Coll, Dept Microbiol & Immunol, Wuhu 241002, Anhui, Peoples R China
Recommended Citation
GB/T 7714
Liu, Qin,Song, Ping,Zhang, Weiwei,et al. Acid-Sensitive Nanoparticles Based on Molybdenum Disulfide for Photothermal-Chemo Therapy br[J]. ACS BIOMATERIALS SCIENCE & ENGINEERING,2022,8(4):1706-1716.
APA Liu, Qin.,Song, Ping.,Zhang, Weiwei.,Wang, Zhenyu.,Yang, Kai.,...&Ge, Fei.(2022).Acid-Sensitive Nanoparticles Based on Molybdenum Disulfide for Photothermal-Chemo Therapy br.ACS BIOMATERIALS SCIENCE & ENGINEERING,8(4),1706-1716.
MLA Liu, Qin,et al."Acid-Sensitive Nanoparticles Based on Molybdenum Disulfide for Photothermal-Chemo Therapy br".ACS BIOMATERIALS SCIENCE & ENGINEERING 8.4(2022):1706-1716.
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