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A new facile synthesis method of branched PEG
Alternative TitleChem. J. Chin. Univ.-Chin.
He, ML; Su, ZG
2003-08-01
Source PublicationCHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
ISSN0251-0790
Volume24Issue:8Pages:1495-1498
AbstractThe modification of bioactive proteins (peptides, enzymes) by using polyethylene glycol(PEG) has still been 6 hot filed of research. It has-been reported that branched PEG is distinctly superior to linear PEG in the modification of some enzymes. However the existing synthetic methods of branched PEG make it very expensive to be used in research-and practice. In this paper, a kind of branched-PEG was synthesized via conventional methods used in the synthesis of polypeptide (protection condensation, and deprotection) using lysine and mPEG5000 as starting materials. In this method, the most important reaction of forming branched PEG was fulfilled in one step by condensation reaction in organic phase. It makes this method remarkably different from other methods. The reaction condition is mild and the yield of the product(61%) is higher. The characterization of products in different steps is consistent with their structures. the H-1 NMR spectrum of our end product branched PEG tallies with its structure.; The modification of bioactive proteins (peptides, enzymes) by using polyethylene glycol(PEG) has still been 6 hot filed of research. It has-been reported that branched PEG is distinctly superior to linear PEG in the modification of some enzymes. However the existing synthetic methods of branched PEG make it very expensive to be used in research-and practice. In this paper, a kind of branched-PEG was synthesized via conventional methods used in the synthesis of polypeptide (protection condensation, and deprotection) using lysine and mPEG5000 as starting materials. In this method, the most important reaction of forming branched PEG was fulfilled in one step by condensation reaction in organic phase. It makes this method remarkably different from other methods. The reaction condition is mild and the yield of the product(61%) is higher. The characterization of products in different steps is consistent with their structures. the H-1 NMR spectrum of our end product branched PEG tallies with its structure.
KeywordNew Method Synthesis Branched Peg
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
URL查看原文
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000184995100039
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.ipe.ac.cn/handle/122111/5316
Collection研究所(批量导入)
AffiliationChinese Acad Sci, Inst Proc Engn, Natl Lab Biochem Engn, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
He, ML,Su, ZG. A new facile synthesis method of branched PEG[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2003,24(8):1495-1498.
APA He, ML,&Su, ZG.(2003).A new facile synthesis method of branched PEG.CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,24(8),1495-1498.
MLA He, ML,et al."A new facile synthesis method of branched PEG".CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 24.8(2003):1495-1498.
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