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Coordination-assembled myricetin nanoarchitectonics for sustainably scavenging free radicals
Ma, Xiaoyan1,2; Gong, Haoning2; Ogino, Kenji1; Yan, Xuehai2,3; Xing, Ruirui2,3
2022-03-01
Source PublicationBEILSTEIN JOURNAL OF NANOTECHNOLOGY
ISSN2190-4286
Volume13Pages:284-291
AbstractOxidative stress can lead to permanent and irreversible damage to cellular components and even cause cancer and other diseases. Therefore, the development of antioxidative reagents is an important strategy to alleviate chronic diseases and maintain the redox balance in cells. Small-molecule bioactive compounds have exhibited huge therapeutic potential as antioxidants and anti-inflammatory agents. Myricetin (Myr), a well-known natural flavonoid, has drawn wide attention because of its high antioxidant, anti-inflammatory, antimicrobial, and anticancer efficacy. Especially regarding antioxidation, Myr is capable of not only chelating intracellular transition metal ions for removing reactive oxygen species, but also of activating antioxidant enzymes and related signal pathways and, thus, of sustainably scavenging radicals. However, Myr is poorly soluble in water, which limits its bioavailability for biomedical applications, and even its clinical therapeutic potential. The antioxidant peptide glutathione (GSH) plays a role as antioxidant in cells and possesses good hydrophilicity and biocompatibility. However, it is easily metabolized by enzymes. To take advantages of their antioxidation activity and to overcome the abovementioned limitations, GSH, Zn2+, and Myr were selected to co-assemble into Myr-Zn2+-GSH nanoparticles or nanoarchitectonics. This study offers a new design to harness stable, sustainable antioxidant nanoparticles with high loading capacity, high bioavailability, and good biocompatibility as antioxidants.
Keywordantioxidant co-assembly glutathione myricetin nanoarchitectonics
DOI10.3762/bjnano.13.23
Language英语
WOS KeywordOXIDATIVE STRESS ; NANOPARTICLES ; ANTIOXIDANT ; DELIVERY ; STABILITY
Funding ProjectInnovation Research Community Science Fund of China[21821005] ; National Natural Science Foundation of China[22072154] ; National Natural Science Foundation of China[21977095] ; Key Research Program of Fron-tier Sciences of Chinese Academy of Sciences (CAS)[QYZDB-SSWJSC034] ; National Natural Science Foun-dation of Hebei Province[B2020103025]
WOS Research AreaScience & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
Funding OrganizationInnovation Research Community Science Fund of China ; National Natural Science Foundation of China ; Key Research Program of Fron-tier Sciences of Chinese Academy of Sciences (CAS) ; National Natural Science Foun-dation of Hebei Province
WOS IDWOS:000789106300001
PublisherBEILSTEIN-INSTITUT
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/53168
Collection中国科学院过程工程研究所
Corresponding AuthorOgino, Kenji; Xing, Ruirui
Affiliation1.Tokyo Univ Agr & Technol, Grad Sch Bioapplicat & Syst Engn, Tokyo, Japan
2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing, Peoples R China
3.Univ Chinese Acad Sci, Sch Chem Engn, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Ma, Xiaoyan,Gong, Haoning,Ogino, Kenji,et al. Coordination-assembled myricetin nanoarchitectonics for sustainably scavenging free radicals[J]. BEILSTEIN JOURNAL OF NANOTECHNOLOGY,2022,13:284-291.
APA Ma, Xiaoyan,Gong, Haoning,Ogino, Kenji,Yan, Xuehai,&Xing, Ruirui.(2022).Coordination-assembled myricetin nanoarchitectonics for sustainably scavenging free radicals.BEILSTEIN JOURNAL OF NANOTECHNOLOGY,13,284-291.
MLA Ma, Xiaoyan,et al."Coordination-assembled myricetin nanoarchitectonics for sustainably scavenging free radicals".BEILSTEIN JOURNAL OF NANOTECHNOLOGY 13(2022):284-291.
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