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Three-dimensional quantitative structure-activity relationship study of tyrosine kinase inhibitors
Alternative TitleActa Phys.-Chim. Sin.
Peng, T; Pei, HF; Zhou, JJ
2003-02-01
Source PublicationACTA PHYSICO-CHIMICA SINICA
ISSN1000-6818
Volume19Issue:2Pages:163-166
AbstractThree-dimensional quantitative structure-activity relationships of isoflavone and quinolone derivatives as tyrosine kinase inhibitors were studied using the flexible atom receptor model (FLARM) method. Some 3D-QSAR models were built with high correlation coefficients. The flexible atom receptor model also gives the pseudo receptor model, which indicates possible interactions between receptor and the ligand. The possible interactions between the ligand and the receptor in the pseudo receptor model are in accordance with those in the Novartis pharmacophore model.; Three-dimensional quantitative structure-activity relationships of isoflavone and quinolone derivatives as tyrosine kinase inhibitors were studied using the flexible atom receptor model (FLARM) method. Some 3D-QSAR models were built with high correlation coefficients. The flexible atom receptor model also gives the pseudo receptor model, which indicates possible interactions between receptor and the ligand. The possible interactions between the ligand and the receptor in the pseudo receptor model are in accordance with those in the Novartis pharmacophore model.
KeywordTyrosine Kinase Inhibitor 3d-qsar Flexible Atom Receptor Model
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
DOI10.3866/PKU.WHXB20030215
URL查看原文
Indexed BySCI
Language英语
WOS KeywordDESIGN
WOS Research AreaChemistry
WOS SubjectChemistry, Physical
WOS IDWOS:000181098000015
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.ipe.ac.cn/handle/122111/5368
Collection研究所(批量导入)
AffiliationChinese Acad Sci, Inst Proc Engn, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Peng, T,Pei, HF,Zhou, JJ. Three-dimensional quantitative structure-activity relationship study of tyrosine kinase inhibitors[J]. ACTA PHYSICO-CHIMICA SINICA,2003,19(2):163-166.
APA Peng, T,Pei, HF,&Zhou, JJ.(2003).Three-dimensional quantitative structure-activity relationship study of tyrosine kinase inhibitors.ACTA PHYSICO-CHIMICA SINICA,19(2),163-166.
MLA Peng, T,et al."Three-dimensional quantitative structure-activity relationship study of tyrosine kinase inhibitors".ACTA PHYSICO-CHIMICA SINICA 19.2(2003):163-166.
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