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Repeated fed-batch lactic acid production in a packed bed-stirred fermentor system using a pH feedback feeding method
Zhang, Yong1,2; Cong, Wei1; Shi, Shao Yuan1; Cong, W
2011
Source PublicationBIOPROCESS AND BIOSYSTEMS ENGINEERING
ISSN1615-7591
Volume34Issue:1Pages:67-73
AbstractLactic acid production by repeated fed-batch fermentation using free and immobilized cells of Lactobacillus lactis-11 in a packed bed-stirred fermentor (PBSF) system filled with different support materials including ceramic beads, macro-activated carbon cylinders and glass fiber balls was investigated. The results showed that the optimal support materials were the ceramic beads with diameters of 1-2 mm. Compared with the free cell fermentation system, lactic acid production and volumetric productivity in the PBSF system increased by 16.6 and 12.5%, respectively. Though the concentration of free cells decreased sharply, lactic acid production remained stable in five consecutive fed-batch runs using the PBSF system. pH gradients, immobilized cell concentration and mass diffusion in the packed bed were all affected by the recirculation rate of the culture broth. Maximum lactic acid production, productivity and yield occurred at a recirculation rate of 50 mL min(-1).
KeywordLactic Acid Packed Bed-stirred Fermentor Ph Feedback Recirculation Lactobacillus Lactis-11
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Technology
DOI10.1007/s00449-010-0447-1
Indexed BySCI
Language英语
WOS KeywordIMMOBILIZED LACTOBACILLUS-CASEI ; WHEY PERMEATE ; PROPIONATE PRODUCTION ; RHIZOPUS-ORYZAE ; FLUIDIZED-BED ; BIOREACTOR ; CELLS ; HELVETICUS ; SUPPORTS ; CULTURE
WOS Research AreaBiotechnology & Applied Microbiology ; Engineering
WOS SubjectBiotechnology & Applied Microbiology ; Engineering, Chemical
WOS IDWOS:000285786300007
Citation statistics
Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.ipe.ac.cn/handle/122111/5382
Collection生化工程国家重点实验室
Corresponding AuthorCong, W
Affiliation1.Chinese Acad Sci, Natl Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Yong,Cong, Wei,Shi, Shao Yuan,et al. Repeated fed-batch lactic acid production in a packed bed-stirred fermentor system using a pH feedback feeding method[J]. BIOPROCESS AND BIOSYSTEMS ENGINEERING,2011,34(1):67-73.
APA Zhang, Yong,Cong, Wei,Shi, Shao Yuan,&Cong, W.(2011).Repeated fed-batch lactic acid production in a packed bed-stirred fermentor system using a pH feedback feeding method.BIOPROCESS AND BIOSYSTEMS ENGINEERING,34(1),67-73.
MLA Zhang, Yong,et al."Repeated fed-batch lactic acid production in a packed bed-stirred fermentor system using a pH feedback feeding method".BIOPROCESS AND BIOSYSTEMS ENGINEERING 34.1(2011):67-73.
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