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Apoferritin-camouflaged Pt nanoparticles: surface effects on cellular uptake and cytotoxicity
Liu, Xiangyou1,2,3; Wei, Wei4; Wang, Chunlei5; Yue, Hua4; Ma, Ding1; Zhu, Cheng1; Ma, Guanghui4; Du, Yuguang2; Ma, D
2011
Source PublicationJOURNAL OF MATERIALS CHEMISTRY
ISSN0959-9428
Volume21Issue:20Pages:7105-7110
AbstractApoferritin-encapsulated Pt nanoparticles (AFt-Pt) were bio-mimetically prepared by an in situ reduction method in the unique 8 nm spherical cage of apoferritin. The average size of AFt-Pt was 4.3 +/- 0.9 nm. The spherical structure of apoferritin remained intact after loading Pt particles in its cavity. Apoferritin coating increased the amount of Pt internalized in HepG2 cells by about three times via receptor-mediated endocytosis. AFt-Pt showed greatly improved biocompatibility compared with polyvinylpyrrolidone stabilized Pt nanoparticles (PVP-Pt). More than 80% of cells survived after treatment with 100 mM AFt-Pt for 48 h. By camouflaging the particles with a protein corona, apoferritin conferred a cell-recognizable identity to the particles, which strikingly ameliorated the bio-effects of the nanoparticles.
KeywordHorse Spleen Apoferritin Platinum Nanoparticle Protein Cages Iron Release Ferritin Cells Biocompatibility Liver
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences ; Technology
DOI10.1039/c1jm10575b
Indexed BySCI
Language英语
WOS KeywordHORSE SPLEEN APOFERRITIN ; PLATINUM NANOPARTICLE ; PROTEIN CAGES ; IRON RELEASE ; FERRITIN ; CELLS ; BIOCOMPATIBILITY ; LIVER
WOS Research AreaChemistry ; Materials Science
WOS SubjectChemistry, Physical ; Materials Science, Multidisciplinary
WOS IDWOS:000290167200010
Citation statistics
Cited Times:34[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.ipe.ac.cn/handle/122111/5395
Collection生化工程国家重点实验室
Corresponding AuthorMa, D
Affiliation1.Peking Univ, Coll Chem & Mol Engn, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
3.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
5.Dalian Univ Technol, Sch Chem Engn, Carbon Res Lab, Dalian 116024, Peoples R China
Recommended Citation
GB/T 7714
Liu, Xiangyou,Wei, Wei,Wang, Chunlei,et al. Apoferritin-camouflaged Pt nanoparticles: surface effects on cellular uptake and cytotoxicity[J]. JOURNAL OF MATERIALS CHEMISTRY,2011,21(20):7105-7110.
APA Liu, Xiangyou.,Wei, Wei.,Wang, Chunlei.,Yue, Hua.,Ma, Ding.,...&Ma, D.(2011).Apoferritin-camouflaged Pt nanoparticles: surface effects on cellular uptake and cytotoxicity.JOURNAL OF MATERIALS CHEMISTRY,21(20),7105-7110.
MLA Liu, Xiangyou,et al."Apoferritin-camouflaged Pt nanoparticles: surface effects on cellular uptake and cytotoxicity".JOURNAL OF MATERIALS CHEMISTRY 21.20(2011):7105-7110.
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