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| Shape Designed Implanted Drug Delivery System for In Situ Hepatocellular Carcinoma Therapy | |
| Zhao, Chaochao1,2; Shi, Qin3,4; Li, Hu2; Cui, Xi2,5; Xi, Yuan2; Cao, Yu2; Xiang, Zhuo6; Li, Feng2,6; Sun, Jinyan1,7; Liu, Jiacheng3; Li, Tongqiang3; Wei, Wei7; Xiong, Bin3; Li, Zhou2,5,6 | |
| 2022-05-24 | |
| Source Publication | ACS NANO
 |
| ISSN | 1936-0851 |
| Volume | 16Issue:5Pages:8493-8503 |
| Abstract | In this study, an intelligent drug delivery system (DDS) based on implanted triboelectric nanogenerator (iTENG) and red blood cell (RBC) is established for in situ hepatocellular carcinoma (HCC) therapy. Apatinib (APA), as an oral antitumor drug, which can inhibit the expression of iTENG vascular endothelial growth factor receptor-2 (VEGFR2) is loaded inside RBC, realizing the transform from oral APA Release formulation to injection preparation. Multishape designed iTENG adapted for different implant sites and environments can harvest biomechanical energy efficiently. The electric field EF) generated by the iTENG can increase the release of APA, and the release will decrease quickly when the EF disappears, which shows that the DDS is highly controllable. The controllable DDS demonstrates an exciting killing ability of HCC cells both in vitro and in vivo with strikingly reduced APA dosage. After implantation, the self-powered DDS has a prominent therapeutic effect of HCC-bearing rabbits, which is expected to be applied in clinical medicine. |
| Keyword | hepatocellular carcinoma self-powered apatinib triboelectric nanogenerator drug delivery |
| DOI | 10.1021/acsnano.2c03768 |
| Language | 英语 |
| WOS Keyword | COMBINATION THERAPY ; APATINIB ; CELL ; PROLIFERATION |
| Funding Project | National Natural Science Foundation of China[T2125003] ; National Natural Science Foundation of China[61875015] ; National Natural Science Foundation of China[82001981] ; National Natural Science Foundation of China[81873917] ; Foshan Bureau of Finance: Developmental and Applied Basic Research of Advanced Technology in Stomatology[CGQ020] ; Guangdong Basic and Applied Basic Research Foundation[2019A1515110639] ; Scientific Research Foundation for Advanced Scholars of Foshan University[Gg07247] ; Scientific Research Foundation for Advanced Scholars of Foshan University[Gg07164] ; Beijing Natural Science Foundation[JQ20038] |
| WOS Research Area | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| WOS Subject | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| Funding Organization | National Natural Science Foundation of China ; Foshan Bureau of Finance: Developmental and Applied Basic Research of Advanced Technology in Stomatology ; Guangdong Basic and Applied Basic Research Foundation ; Scientific Research Foundation for Advanced Scholars of Foshan University ; Beijing Natural Science Foundation |
| WOS ID | WOS:000812148900121 |
| Publisher | AMER CHEMICAL SOC |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/54049 |
| Collection | 中国科学院过程工程研究所 |
| Corresponding Author | Xiong, Bin; Li, Zhou |
| Affiliation | 1.Foshan Univ, Sch Med, Dept Biomed Engn, Foshan 528225, Peoples R China 2.Chinese Acad Sci, Beijing Inst Nanoenergy & Nanosyst, Beijing Key Lab Micronano Energy & Sensor, CAS Ctr Excellence Nanosci, Beijing 101400, Peoples R China 3.Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Radiol, Wuhan 430022, Peoples R China 4.Fudan Univ, Zhongshan Hosp, Dept Intervent Radiol, Shanghai 200032, Peoples R China 5.Univ Chinese Acad Sci, Sch Nanosci & Technol, Beijing 100049, Peoples R China 6.Guangxi Univ, Ctr Nanoenergy Res, Sch Phys Sci & Technol, Nanning 530004, Peoples R China 7.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China |
| Recommended Citation GB/T 7714 | Zhao, Chaochao,Shi, Qin,Li, Hu,et al. Shape Designed Implanted Drug Delivery System for In Situ Hepatocellular Carcinoma Therapy[J]. ACS NANO,2022,16(5):8493-8503. |
| APA | Zhao, Chaochao.,Shi, Qin.,Li, Hu.,Cui, Xi.,Xi, Yuan.,...&Li, Zhou.(2022).Shape Designed Implanted Drug Delivery System for In Situ Hepatocellular Carcinoma Therapy.ACS NANO,16(5),8493-8503. |
| MLA | Zhao, Chaochao,et al."Shape Designed Implanted Drug Delivery System for In Situ Hepatocellular Carcinoma Therapy".ACS NANO 16.5(2022):8493-8503. |
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