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| PEG-Functionalized Hollow Multishelled Structures with On-Off Switch and Rate-Regulation for Controllable Antimicrobial Release | |
| Zhao, Decai1; Wei, Yanze1; Jin, Quan1; Yang, Nailiang1,2; Yang, Yang3; Wang, Dan1,2 | |
| 2022-07-27 | |
| Source Publication | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
 |
| ISSN | 1433-7851 |
| Pages | 7 |
| Abstract | The construction of responsive antimicrobial carriers with multifunctional and controllable release is an attractive but challenging proposition. Recently developed hollow multishelled structures (HoMSs) offers structural advantages, such as easily modifiable surfaces and mutually influenced shells. Herein, we report a novel pH-responsive antimicrobial carrier having hierarchical shells as multilevel responsive bodies using polyethylene glycol (PEG) as a gated regulator. The interaction between PEG-functionalized shells endows them with a pH-responsive switch and rate-regulator capability. These features are present in the form of rapid release of molecules wrapped in the outer shell, and controlled diffusion of antimicrobials stored in the inner shell by electrostatic interaction, resulting in a long-lasting mildew resistance for up to 71 days. The versatility of the hierarchical interactions of HoMSs will inspire the design of promising smart drug carriers. |
| Keyword | Antimicrobial Controlled Release Hollow Multishelled Structure PEG-Functionalization pH-Responsive |
| DOI | 10.1002/anie.202206807 |
| Language | 英语 |
| WOS Keyword | POLY(ETHYLENE GLYCOL) ; POLYETHYLENE-GLYCOL ; ADSORPTION ; PH ; OXIDE) |
| Funding Project | National Natural Science Foundation of China[21821005] ; National Natural Science Foundation of China[52072369] ; National Natural Science Foundation of China[92163209] |
| WOS Research Area | Chemistry |
| WOS Subject | Chemistry, Multidisciplinary |
| Funding Organization | National Natural Science Foundation of China |
| WOS ID | WOS:000830728100001 |
| Publisher | WILEY-V C H VERLAG GMBH |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/54304 |
| Collection | 中国科学院过程工程研究所 |
| Corresponding Author | Yang, Nailiang; Yang, Yang; Wang, Dan |
| Affiliation | 1.Inst Proc Engn, State Key Lab Biochem Engn, 1 North 2nd St, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 10049, Peoples R China 3.Tongji Univ, Shanghai Pulm Hosp, Inst Adv Study, Dept Thorac Surg, Shanghai 200430, Peoples R China |
| Recommended Citation GB/T 7714 | Zhao, Decai,Wei, Yanze,Jin, Quan,et al. PEG-Functionalized Hollow Multishelled Structures with On-Off Switch and Rate-Regulation for Controllable Antimicrobial Release[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2022:7. |
| APA | Zhao, Decai,Wei, Yanze,Jin, Quan,Yang, Nailiang,Yang, Yang,&Wang, Dan.(2022).PEG-Functionalized Hollow Multishelled Structures with On-Off Switch and Rate-Regulation for Controllable Antimicrobial Release.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,7. |
| MLA | Zhao, Decai,et al."PEG-Functionalized Hollow Multishelled Structures with On-Off Switch and Rate-Regulation for Controllable Antimicrobial Release".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022):7. |
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