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| In vitro and in vivo low-dose exposure of simulated cooking oil fumes to assess adverse biological effects | |
Li, Shuangde1; Wang, Li2; Guan, Shanyue2; Zhou, Shuyun2; Chen, Yunfa1,3
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| 2022-09-20 | |
| Source Publication | SCIENTIFIC REPORTS
 |
| ISSN | 2045-2322 |
| Volume | 12Issue:1Pages:11 |
| Abstract | Cooking oil fumes (COFs) represent a major indoor environmental pollutant and exhibit potent mutagenic or carcinogenic health effects caused by containing various heterocyclic aromatic amines (HAAs) and long-chain aldehydes. Despite some evaluation of the cumulative exposure of COFs to cancer cells under high concentration were evaluated, their biological adverse effects with low-dose exposure to healthy cells had been inadequately investigated. Herein, we firstly scrutinized the three selected typically toxic compounds of heterocyclic amine 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), 3,8-dimethylammidazo[4,5-f]quinoxalin-2-amine (MeIQx) and trans, trans-2,4-decadienal (TDA)) emitted from COFs. In vitro studies revealed that the PhIP, MeIQx and TDA aerosol particles were negligible toxicity to cancer cells (A549 and HepG-2) but strong cytotoxicity to normal healthy cells (HelF and L02) under 0.5-4 mu g/mL low dose exposure based on the reactive oxygen species (ROS) mechanism. In vivo studies demonstrated that PhIP caused significant lung and liver damage after exposure to PhIP for 30 days with mice. These results indicated the direct proof of healthy cell damage even at low-dose exposure to HAAs and aldehydes. |
| DOI | 10.1038/s41598-022-19558-x |
| Language | 英语 |
| WOS Keyword | LUNG-CANCER ; CHINESE COOKING ; EMISSIONS ; PROLIFERATION ; GENOTOXICITY ; CARCINOGEN ; COMPOUND ; HAZARDS ; PATHWAY ; PHIP |
| Funding Project | Open Research Fund of State Key Laboratory of Multiphase Complex Systems[MPCS-2019-D-06] ; Youth Innovation Promotion Association of Chinese Academy of Sciences[2018062] |
| WOS Research Area | Science & Technology - Other Topics |
| WOS Subject | Multidisciplinary Sciences |
| Funding Organization | Open Research Fund of State Key Laboratory of Multiphase Complex Systems ; Youth Innovation Promotion Association of Chinese Academy of Sciences |
| WOS ID | WOS:000857187000036 |
| Publisher | NATURE PORTFOLIO |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/54668 |
| Collection | 中国科学院过程工程研究所 |
| Corresponding Author | Guan, Shanyue; Chen, Yunfa |
| Affiliation | 1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Multiphase Complex Syst, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Phys & Chem, Key Lab Photochem Convers & Optoelect Mat Tech, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| Recommended Citation GB/T 7714 | Li, Shuangde,Wang, Li,Guan, Shanyue,et al. In vitro and in vivo low-dose exposure of simulated cooking oil fumes to assess adverse biological effects[J]. SCIENTIFIC REPORTS,2022,12(1):11. |
| APA | Li, Shuangde,Wang, Li,Guan, Shanyue,Zhou, Shuyun,&Chen, Yunfa.(2022).In vitro and in vivo low-dose exposure of simulated cooking oil fumes to assess adverse biological effects.SCIENTIFIC REPORTS,12(1),11. |
| MLA | Li, Shuangde,et al."In vitro and in vivo low-dose exposure of simulated cooking oil fumes to assess adverse biological effects".SCIENTIFIC REPORTS 12.1(2022):11. |
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