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| Preparation, characterization, and physicochemical property of the inclusion complexes of Cannabisin A with ,B-cyclodextrin and hydroxypropyl- ,B-cyclodextrin | |
Xu, Peng-Wei1,2; Yuan, Xiao-Fan1 ; Li, Hang1,2; Zhu, Yuan1,2; Zhao, Bing1
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| 2023-01-15 | |
| Source Publication | JOURNAL OF MOLECULAR STRUCTURE
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| ISSN | 0022-2860 |
| Volume | 1272Pages:11 |
| Abstract | Cannabisin A (CA), derived from hemp seed shells, has antioxidant and anti-neuroinflammatory activity. However, its application is limited due to its poor solubility. In this work, ,B-cyclodextrin ( ,B-CD) and HP-,B-cyclodextrin (HP -,B-) were used to encapsulate CA to increase its water-solubility. The inclusion complexes of CA with ,B-CD (CA/,B-CD IC) and the inclusion complexes of CA with HP -,B-CD (CA/HP-,B- CD IC) were prepared by the aqueous ethanol solution method. The Job's plot assay and Phase solubility assay revealed that the inclusion complexes of CA with ,B-CD/HP-,B-CD formed at a 1:1 stoichiometric ratio. However, considering the inclusion process is reversible, the inclusion complexes were prepared at a 1:2 molar ratio. The structure of the inclusion complexes was identified by FT-IR, XRD, DSC, SEM, and NMR. In addition, the results of1 H NMR, 2D ROESY NMR, and molecular docking further determined the possible conformations of the inclusion complexes. The solubility of the CA in the CA/,B-CD IC and CA/HP-,B-CD IC was increased by 13.95-fold and 56.37-fold, respectively, compared to pure CA; and the dissolution and antioxidant activity of the CA were also significantly promoted after complexation. This study proved that CA/HP-,B-CD IC was the preferred inclusion complex compared to CA/,B-CD IC due to its better physicochemical properties. (c) 2022 Published by Elsevier B.V. |
| Keyword | Cannabisin A Hemp seed B -cyclodextrin Hydroxypropyl Inclusion complexes Encapsulation |
| DOI | 10.1016/j.molstruc.2022.134168 |
| Language | 英语 |
| WOS Keyword | SATIVA L. SEED ; BETA-CYCLODEXTRINS ; CHLOROGENIC ACID ; TRANS-ANETHOLE ; SOLUBILITY ; STABILITY ; BEHAVIOR ; FRUITS ; LIGNANAMIDES |
| Funding Project | Yunnan Hanmeng Pharmaceutical Co. Ltd, (Yunnan, China) |
| WOS Research Area | Chemistry |
| WOS Subject | Chemistry, Physical |
| Funding Organization | Yunnan Hanmeng Pharmaceutical Co. Ltd, (Yunnan, China) |
| WOS ID | WOS:000863986500002 |
| Publisher | ELSEVIER |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/54994 |
| Collection | 中国科学院过程工程研究所 |
| Corresponding Author | Yuan, Xiao-Fan; Zhao, Bing |
| Affiliation | 1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| Recommended Citation GB/T 7714 | Xu, Peng-Wei,Yuan, Xiao-Fan,Li, Hang,et al. Preparation, characterization, and physicochemical property of the inclusion complexes of Cannabisin A with ,B-cyclodextrin and hydroxypropyl- ,B-cyclodextrin[J]. JOURNAL OF MOLECULAR STRUCTURE,2023,1272:11. |
| APA | Xu, Peng-Wei,Yuan, Xiao-Fan,Li, Hang,Zhu, Yuan,&Zhao, Bing.(2023).Preparation, characterization, and physicochemical property of the inclusion complexes of Cannabisin A with ,B-cyclodextrin and hydroxypropyl- ,B-cyclodextrin.JOURNAL OF MOLECULAR STRUCTURE,1272,11. |
| MLA | Xu, Peng-Wei,et al."Preparation, characterization, and physicochemical property of the inclusion complexes of Cannabisin A with ,B-cyclodextrin and hydroxypropyl- ,B-cyclodextrin".JOURNAL OF MOLECULAR STRUCTURE 1272(2023):11. |
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