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| Green Extraction of Forsythoside A, Phillyrin and Phillygenol from Forsythia suspensa Leaves Using a beta-Cyclodextrin-Assisted Method | |
Li, Jing1,2; Qin, Qiao1,3; Zha, Sheng-Hua4; Zhao, Qing-Sheng3 ; Li, Hang3; Liu, Lu-Peng1,3; Hou, Shou-Bu3; Zhao, Bing3
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| 2022-10-01 | |
| Source Publication | MOLECULES
 |
| Volume | 27Issue:20Pages:17 |
| Abstract | In this study, a green process of beta-cyclodextrin (beta-CD)-assisted extraction of active ingredients from Forsythia suspensa leaves was developed. Firstly, the optimal process of extraction was as follows: the ratio between Forsythia suspensa leaves and beta-CD was 3.61:5, the solid-liquid ratio was 1:36.3, the temperature was 75.25 degrees C and the pH was 3.94. The yields of forsythoside A, phillyrin and phillygenol were 11.80 +/- 0.141%, 5.49 +/- 0.078% and 0.319 +/- 0.004%, respectively. Then, the structure characteristics of the beta-CD-assisted extract of Forsythia suspensa leaves (FSE-beta-CD) were analyzed using powder X-ray diffraction (PXRD), Fourier transform infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC), scanning electron microscopy (SEM) and molecular docking to demonstrate that the natural active products from Forsythia suspensa leaves had significant interactions with the beta-CD. Additionally, the loss of forsythoside A from aqueous FSE-CD at 80 degrees C was only 12%, compared with Forsythia suspensa leaf extract (FSE) which decreased by 13%. In addition, the aqueous solubility of FSE-CD was significantly increased to 70.2 g/L. The EC50 for scavenging DPPH and ABTS radicals decreased to 28.98 ug/mL and 25.54 ug/mL, respectively. The results showed that the beta-CD-assisted extraction process would be a promising technology for bioactive compounds extracted from plants. |
| Keyword | Forsythia suspensa leaves beta-cyclodextrins response surface methodology stability antioxidant activity |
| DOI | 10.3390/molecules27207055 |
| Language | 英语 |
| WOS Keyword | THUNB. VAHL ; COMPONENTS ; COMPLEXES |
| Funding Project | Hebei University of Economics and Business[B20221002] ; [JXT2020YB05] |
| WOS Research Area | Biochemistry & Molecular Biology ; Chemistry |
| WOS Subject | Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary |
| Funding Organization | Hebei University of Economics and Business |
| WOS ID | WOS:000873263200001 |
| Publisher | MDPI |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/55239 |
| Collection | 中国科学院过程工程研究所 |
| Corresponding Author | Zha, Sheng-Hua; Zhao, Qing-Sheng |
| Affiliation | 1.Hebei Univ Econ & Business, Coll Biosci & Engn, Shijiazhuang 050061, Hebei, Peoples R China 2.Hebei Univ Sci & Technol, Coll Food & Biol, Shijiazhuang 050018, Hebei, Peoples R China 3.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 4.Beijing Tong Ren Tang Hlth Pharmaceut Co Ltd, Beijing 100085, Peoples R China |
| Recommended Citation GB/T 7714 | Li, Jing,Qin, Qiao,Zha, Sheng-Hua,et al. Green Extraction of Forsythoside A, Phillyrin and Phillygenol from Forsythia suspensa Leaves Using a beta-Cyclodextrin-Assisted Method[J]. MOLECULES,2022,27(20):17. |
| APA | Li, Jing.,Qin, Qiao.,Zha, Sheng-Hua.,Zhao, Qing-Sheng.,Li, Hang.,...&Zhao, Bing.(2022).Green Extraction of Forsythoside A, Phillyrin and Phillygenol from Forsythia suspensa Leaves Using a beta-Cyclodextrin-Assisted Method.MOLECULES,27(20),17. |
| MLA | Li, Jing,et al."Green Extraction of Forsythoside A, Phillyrin and Phillygenol from Forsythia suspensa Leaves Using a beta-Cyclodextrin-Assisted Method".MOLECULES 27.20(2022):17. |
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