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| Transformable Nanotheranostics Capable of Sensoring Nucleic Acid Drugs' Spatiotemporal Behaviors | |
| Shen, Jie1,2; Wang, Jingwen1; Hao, Qiulian1; Ji, Weihong2; Peng, Huan1,2; Wu, Yanyue1,2; Zhao, Ruichen1,2; Qiu, Xinyu1; Wang, Wenli1; Yang, Jun1,2; Li, Yan1; Zhang, Tianlu1; Lu, Zhiguo1,2; Zhang, Xin1,2 | |
| 2022-11-27 | |
| Source Publication | ADVANCED FUNCTIONAL MATERIALS
 |
| ISSN | 1616-301X |
| Pages | 11 |
| Abstract | Nanotheranostics facilitates personalized treatment by providing imaging capabilities for nucleic acid drug vectors. However, available nanotheranostics are not yet capable of indicating the release behavior of nucleic acid drugs. Herein, four guidelines for the design of nanotheranostics are proposed. Under the guidance, transformable nanotheranostics are prepared that can sense the spatiotemporal behaviors of siRNA accumulation and release to facilitate personalized oncology treatment. The nanotheranostics sense the spatiotemporal accumulation behavior of siRNA in tumors through computerized tomography. Besides, the tumor cytoplasmic microenvironment mediates both siRNA release and nanotherapeutic agent transformation simultaneously. The transformation-activated magnetic resonance imaging (MRI) signals sense the spatiotemporal release behavior of siRNA. Moreover, the therapeutic effect of survivin-targeted siRNA can be diagnosed and confirmed by contrast-enhanced CT/MRI multi-modal imaging in real-time. The transformable nanotheranostics further promote personalized oncotherapy by nucleic acid drugs. These four guidelines are expected to direct the research and development of nucleic acid drug-based nanotheranostics. This study also provides a new perspective on real-time sensoring the spatiotemporal behaviors of nucleic acid drugs in vivo. |
| Keyword | contrast-enhanced CT MRI multi-modal imaging personalized oncotherapy spatiotemporal behaviors of nucleic acid drugs transformable nanotheranostics |
| DOI | 10.1002/adfm.202209749 |
| Language | 英语 |
| WOS Keyword | SURVIVIN EXPRESSION ; RNA ; DELIVERY ; CARCINOMA ; THERAPY ; GROWTH ; CANCER ; GENE |
| Funding Project | National Natural Science Foundation of China ; China Postdoctoral Science Foundation ; [22205240] ; [32225029] ; [52073287] ; [31771095] ; [21875254] ; [22075289] ; [2021M703240] |
| WOS Research Area | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS Subject | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
| Funding Organization | National Natural Science Foundation of China ; China Postdoctoral Science Foundation |
| WOS ID | WOS:000890361800001 |
| Publisher | WILEY-V C H VERLAG GMBH |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/55915 |
| Collection | 中国科学院过程工程研究所 |
| Corresponding Author | Lu, Zhiguo; Zhang, Xin |
| Affiliation | 1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China |
| Recommended Citation GB/T 7714 | Shen, Jie,Wang, Jingwen,Hao, Qiulian,et al. Transformable Nanotheranostics Capable of Sensoring Nucleic Acid Drugs' Spatiotemporal Behaviors[J]. ADVANCED FUNCTIONAL MATERIALS,2022:11. |
| APA | Shen, Jie.,Wang, Jingwen.,Hao, Qiulian.,Ji, Weihong.,Peng, Huan.,...&Zhang, Xin.(2022).Transformable Nanotheranostics Capable of Sensoring Nucleic Acid Drugs' Spatiotemporal Behaviors.ADVANCED FUNCTIONAL MATERIALS,11. |
| MLA | Shen, Jie,et al."Transformable Nanotheranostics Capable of Sensoring Nucleic Acid Drugs' Spatiotemporal Behaviors".ADVANCED FUNCTIONAL MATERIALS (2022):11. |
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