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| Virus-like Particles for TEM Regulation and Antitumor Therapy | |
| Yang, Zhu1,2; Chi, Yongjie1,2; Bao, Jiaxin1,3; Zhao, Xin1,3; Zhang, Jing1,2; Wang, Lianyan1,2 | |
| 2022-12-01 | |
| Source Publication | JOURNAL OF FUNCTIONAL BIOMATERIALS
 |
| Volume | 13Issue:4Pages:13 |
| Abstract | Tumor development and metastasis are intimately associated with the tumor microenvironment (TME), and it is difficult for vector-restricted drugs to act on the TME for long-term cancer immunotherapy. Virus-like particles (VLPs) are nanocage structures self-assembled from nucleic acid free viral proteins. Most VLPs range from 20-200 nm in diameter and can naturally drain into lymph nodes to induce robust humoral immunity. As natural nucleic acid nanocarriers, their surfaces can also be genetically or chemically modified to achieve functions such as TME targeting. This review focuses on the design ideas of VLP as nanocarriers and the progress of their research in regulating TME. |
| Keyword | virus-like particle tumor microenvironment immunotherapy nanovaccine |
| DOI | 10.3390/jfb13040304 |
| Language | 英语 |
| WOS Keyword | TUMOR MICROENVIRONMENT ; CANCER-IMMUNOTHERAPY ; TARGETED DELIVERY ; DENDRITIC CELLS ; VACCINE ; NANOPARTICLES ; ANTIGEN ; IMMUNITY ; COMBINATION ; STATISTICS |
| Funding Project | National Natural Science Foundation of China ; Beijing Natural Science Foundation ; [81973262] ; [82011530138] ; [81970660] ; [L202039] |
| WOS Research Area | Engineering ; Materials Science |
| WOS Subject | Engineering, Biomedical ; Materials Science, Biomaterials |
| Funding Organization | National Natural Science Foundation of China ; Beijing Natural Science Foundation |
| WOS ID | WOS:000901318800001 |
| Publisher | MDPI |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/56245 |
| Collection | 中国科学院过程工程研究所 |
| Corresponding Author | Wang, Lianyan |
| Affiliation | 1.Chinese Acad Sci, Inst Proc Engn, Key Lab Green Proc & Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Sch Chem Engn, Beijing, Peoples R China 3.Heilongjiang Univ Tradit Chinese Med, Sch Pharm, Harbin 150040, Peoples R China |
| Recommended Citation GB/T 7714 | Yang, Zhu,Chi, Yongjie,Bao, Jiaxin,et al. Virus-like Particles for TEM Regulation and Antitumor Therapy[J]. JOURNAL OF FUNCTIONAL BIOMATERIALS,2022,13(4):13. |
| APA | Yang, Zhu,Chi, Yongjie,Bao, Jiaxin,Zhao, Xin,Zhang, Jing,&Wang, Lianyan.(2022).Virus-like Particles for TEM Regulation and Antitumor Therapy.JOURNAL OF FUNCTIONAL BIOMATERIALS,13(4),13. |
| MLA | Yang, Zhu,et al."Virus-like Particles for TEM Regulation and Antitumor Therapy".JOURNAL OF FUNCTIONAL BIOMATERIALS 13.4(2022):13. |
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