Knowledge Management System Of Institute of process engineering,CAS
| Surface Self-Assembly of Dipeptides on Porous CaCO3 Particles Promoting Cell Internalization | |
| Ma, Yuqi1; Wang, Anhe1,2; Li, Jieling1,2; Li, Qi1,2; Han, Qingquan1,2; Jing, Yafeng1; Zheng, Xuefang3; Cao, Hongyu3; Yan, Xuehai1,2; Bai, Shuo1,2 | |
| 2022-12-29 | |
| Source Publication | ACS APPLIED MATERIALS & INTERFACES
 |
| ISSN | 1944-8244 |
| Pages | 12 |
| Abstract | The self-assembling behavior of peptides and derivatives is crucial in the natural process to construct various architectures and achieve specific functions. However, the surface or interfacial self assembly, in particular, on the surface of micro-or nanoparticles is even less systematically investigated. Here, uniform porous CaCO3 micro particles were prepared with different charged, hydrophobic and hydrophilic surfaces to assess the self-assembling behavior of dipeptides composed of various sequences. Experimental results indicate that dipeptides with a negative charge in an aqueous solution preferred to self-assemble on the hydrophobic and positively charged surface of CaCO3 particles, which can be ascribed to the electrostatic and hydrophobic interaction between dipeptides and CaCO3 particles. Meanwhile, the Log p (lipid-water partition coefficient) of dipeptides has a significant effect on the self-assembling behavior of dipeptides on the surface of porous CaCO3; dipeptides with high Log p preferred to self-assemble on the surface of CaCO3 particles, resulting in the improved cell internalization efficiency of particles with low cytotoxicity. After loading with a model drug (doxorubicin), the particles show obvious antitumor activity in animal experiments and can reduce Dox side effects effectively. |
| Keyword | peptide self-assembly CaCO3 particles surface modification cell internalization cancer therapy |
| DOI | 10.1021/acsami.2c21447 |
| Language | 英语 |
| WOS Keyword | IN-VITRO ; PEPTIDE ; FABRICATION ; NANOPARTICLES ; ADSORPTION ; VESICLES ; DESIGN ; GOLD ; PH |
| Funding Project | Chinese Major Program for National Key Research and Development Project[2020YFA0112603] ; Strategic Priority Research Program of the Chinese Academy of Science[XDA16020808] ; Beijing Municipal Natural Science Foundation[7212206] ; NationalNatural Science Foundation of China[22072155] ; NationalNatural Science Foundation of China[22002170] ; Project of Young Science and Technology Star of Dalian[2017RQ156] |
| WOS Research Area | Science & Technology - Other Topics ; Materials Science |
| WOS Subject | Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| Funding Organization | Chinese Major Program for National Key Research and Development Project ; Strategic Priority Research Program of the Chinese Academy of Science ; Beijing Municipal Natural Science Foundation ; NationalNatural Science Foundation of China ; Project of Young Science and Technology Star of Dalian |
| WOS ID | WOS:000907016300001 |
| Publisher | AMER CHEMICAL SOC |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/56433 |
| Collection | 中国科学院过程工程研究所 |
| Corresponding Author | Wang, Anhe; Cao, Hongyu; Bai, Shuo |
| Affiliation | 1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Dalian Univ, Coll Life Sci & Biotechnol, Dalian 116622, Peoples R China |
| First Author Affilication | Center of lonic Liquids and Green Engineering |
| Corresponding Author Affilication | Center of lonic Liquids and Green Engineering |
| Recommended Citation GB/T 7714 | Ma, Yuqi,Wang, Anhe,Li, Jieling,et al. Surface Self-Assembly of Dipeptides on Porous CaCO3 Particles Promoting Cell Internalization[J]. ACS APPLIED MATERIALS & INTERFACES,2022:12. |
| APA | Ma, Yuqi.,Wang, Anhe.,Li, Jieling.,Li, Qi.,Han, Qingquan.,...&Bai, Shuo.(2022).Surface Self-Assembly of Dipeptides on Porous CaCO3 Particles Promoting Cell Internalization.ACS APPLIED MATERIALS & INTERFACES,12. |
| MLA | Ma, Yuqi,et al."Surface Self-Assembly of Dipeptides on Porous CaCO3 Particles Promoting Cell Internalization".ACS APPLIED MATERIALS & INTERFACES (2022):12. |
| Files in This Item: | There are no files associated with this item. | |||||
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment