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| Schiff base nanoarchitectonics for supramolecular assembly of dipeptide as drug carriers | |
| Wu, Aoli1,2; Guo, Yongxian2; Li, Xianbao2,3; Li, Qi4; Chen, Guixin1; Zang, Hengchang1; Li, Junbai2,3 | |
| 2023-01-15 | |
| Source Publication | JOURNAL OF COLLOID AND INTERFACE SCIENCE
 |
| ISSN | 0021-9797 |
| Volume | 630Pages:161-169 |
| Abstract | Development of peptide-based supramolecular materials with hierarchical morphology and tunable guest loading displays broad potential as drug carrier in view of biocompatibility and biodegradability. Herein, we report a facile Schiff base nanoarchitectonic for supramolecular assembly of diphenylalanine (FF) metastable gel. The addition of trace glutaraldehyde (GA)/H2O solution induces the Schiff base reaction between GA and FF accompanying by phase transition from gel to solution. FF nanoparticles and hierarchical beaded nanofibers with autofluorescence properties can be constructed by regulating the competitive assembly between FF-H2O and FF-GA oligomer. Moreover, various guest molecules with different hydrophilic and hydrophobic properties can be easily loaded into such assembled particles and its release can be triggered under weak alkaline conditions, which show the potential application of the assembled FF system as drug carriers. (c) 2022 Elsevier Inc. All rights reserved. |
| Keyword | Supramolecular gel Dipeptide Schiff base Drug carrier Autofluorescence |
| DOI | 10.1016/j.jcis.2022.09.122 |
| Language | 英语 |
| WOS Keyword | GLUTARALDEHYDE |
| Funding Project | National Natural Science Foundation of China[21961142022] ; China Postdoctoral Science Foundation[BX20190333] ; China Postdoctoral Science Foundation[2019 M660804] ; Fundamental Research Funds of Shandong University |
| WOS Research Area | Chemistry |
| WOS Subject | Chemistry, Physical |
| Funding Organization | National Natural Science Foundation of China ; China Postdoctoral Science Foundation ; Fundamental Research Funds of Shandong University |
| WOS ID | WOS:000911466200004 |
| Publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/56539 |
| Collection | 中国科学院过程工程研究所 |
| Corresponding Author | Li, Qi; Li, Junbai |
| Affiliation | 1.Shandong Univ, Cheeloo Coll Med, Sch Pharmaceut Sci, NMPA Key Lab Technol Res & Evaluat Drug Prod, Jinan 250012, Shandong, Peoples R China 2.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci BNLMS, CAS Key Lab Colloid Interface & Chem Thermodynam, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China |
| Recommended Citation GB/T 7714 | Wu, Aoli,Guo, Yongxian,Li, Xianbao,et al. Schiff base nanoarchitectonics for supramolecular assembly of dipeptide as drug carriers[J]. JOURNAL OF COLLOID AND INTERFACE SCIENCE,2023,630:161-169. |
| APA | Wu, Aoli.,Guo, Yongxian.,Li, Xianbao.,Li, Qi.,Chen, Guixin.,...&Li, Junbai.(2023).Schiff base nanoarchitectonics for supramolecular assembly of dipeptide as drug carriers.JOURNAL OF COLLOID AND INTERFACE SCIENCE,630,161-169. |
| MLA | Wu, Aoli,et al."Schiff base nanoarchitectonics for supramolecular assembly of dipeptide as drug carriers".JOURNAL OF COLLOID AND INTERFACE SCIENCE 630(2023):161-169. |
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