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Dual responsive copolymer micelles for drug controlled release
Yang, Liangrong; Guo, Chen; Jia, Lianwei; Liang, Xiangfeng; Liu, Chunzhao; Liu, Huizhou; Guo, C
2010-10-01
Source PublicationJOURNAL OF COLLOID AND INTERFACE SCIENCE
ISSN0021-9797
Volume350Issue:1Pages:22-29
AbstractpH- and temperature-responsive polymeric drug carriers based on Chitosan oligosaccharide (CSO)-g-Pluronic copolymers were successfully synthesized for Doxorubicin (DOX) controlled release. The critical aggregation concentration of CSO-g-Pluronic is 0.035 mg/mL at 25 degrees C. The CSO-g-Pluronic and DOX-loaded CSO-g-Pluronic micelles have an average hydrodynamic diameter of 23.3 nm and 43.6 nm respectively at 30 degrees C and pH 7.0 with narrow size distribution. The temperature or pH responsive behavior of the micelles was characterized by dynamic light scattering, fluorescence spectroscopy, and zeta Potential Analysis. The temperature-dependent micellar transformation was induced by dehydration of Pluronic segments at higher temperature. The pH responsive volume increase was traced to the electrostatic repulsion between CSO segments from protonation of amino groups under acidic conditions. Consequently, the DOX release time was prolonged by CSO-g-Pluronic micelles at body temperature of 37 degrees C, and the DOX release was accelerated at mild acidic conditions (i.e. the pH environment around tumor tissues). The temperature- and pH-responsive properties of CSO-g-Pluronic copolymer have provided promising potentials for biomedical and biotechnological applications. (C) 2010 Elsevier Inc. All rights reserved.
KeywordTemperature Responsive Ph Responsive Polymeric Micelles Drug Controlled Release
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
DOI10.1016/j.jcis.2010.04.023
Indexed BySCI
Language英语
WOS KeywordPLURONIC((R)) BLOCK-COPOLYMERS ; AQUEOUS-SOLUTIONS ; AGGREGATION BEHAVIOR ; TRIBLOCK COPOLYMERS ; PEPTIDE DELIVERY ; GRAFTED CHITOSAN ; OXIDE) ; NANOPARTICLES ; TEMPERATURE ; MICELLIZATION
WOS Research AreaChemistry
WOS SubjectChemistry, Physical
WOS IDWOS:000281048300005
Citation statistics
Cited Times:25[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.ipe.ac.cn/handle/122111/5703
Collection湿法冶金清洁生产技术国家工程实验室
Corresponding AuthorGuo, C
AffiliationChinese Acad Sci, Inst Proc Engn, Key Lab Green Proc & Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Yang, Liangrong,Guo, Chen,Jia, Lianwei,et al. Dual responsive copolymer micelles for drug controlled release[J]. JOURNAL OF COLLOID AND INTERFACE SCIENCE,2010,350(1):22-29.
APA Yang, Liangrong.,Guo, Chen.,Jia, Lianwei.,Liang, Xiangfeng.,Liu, Chunzhao.,...&Guo, C.(2010).Dual responsive copolymer micelles for drug controlled release.JOURNAL OF COLLOID AND INTERFACE SCIENCE,350(1),22-29.
MLA Yang, Liangrong,et al."Dual responsive copolymer micelles for drug controlled release".JOURNAL OF COLLOID AND INTERFACE SCIENCE 350.1(2010):22-29.
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