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The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models
Shi, Leming; Campbell, Gregory; Jones, Wendell D.; Oberthuer, Andre; Thomas, Russell S.; Paules, Richard S.; Fielden, Mark; Barlogie, Bart; Chen, Weijie; Du, Pan; Fischer, Matthias; Furlanello, Cesare; Campagne, Fabien; Wen, Zhining; Walker, Stephen J.; Su, Zhenqiang; Chu, Tzu-Ming; Goodsaid, Federico M.; Pusztai, Lajos; Shaughnessy, John D., Jr.; Shi, LM
2010-10
Source PublicationPHARMACOGENOMICS JOURNAL
Issue增刊: SPages:S5-S16
AbstractGene expression data from microarrays are being applied to predict preclinical and clinical endpoints, but the reliability of these predictions has not been established In the MAQC II project, 36 independent teams analyzed six microarray data sets to generate predictive models for classifying a sample with respect to one of 13 endpoints indicative of lung or liver toxicity in rodents, or of breast cancer, multiple myeloma or neuroblastoma in humans In total, >30,000 models were built using many combinations of analytical methods The teams generated predictive models without knowing the biological meaning of some of the endpoints and, to mimic clinical reality, tested the models on data that had not been used for training We found that model performance depended largely on the endpoint and team proficiency and that different approaches generated models of similar performance The conclusions and recommendations from MAQC-II should be useful for regulatory agencies, study committees and independent investigators that evaluate methods for global gene expression analysis
KeywordGene-expression Data Control Maqc Project Published Microarray Follicular Lymphoma Dna Microarrays Breast-cancer One-color Performance Platforms Classification
Indexed BySCI
Language英语
Document Type期刊论文
Version出版稿
Identifierhttp://ir.ipe.ac.cn/handle/122111/5706
Collection多相复杂系统国家重点实验室
Corresponding AuthorShi, LM
Recommended Citation
GB/T 7714
Shi, Leming,Campbell, Gregory,Jones, Wendell D.,et al. The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models[J]. PHARMACOGENOMICS JOURNAL,2010(增刊: S):S5-S16.
APA Shi, Leming.,Campbell, Gregory.,Jones, Wendell D..,Oberthuer, Andre.,Thomas, Russell S..,...&Shi, LM.(2010).The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models.PHARMACOGENOMICS JOURNAL(增刊: S),S5-S16.
MLA Shi, Leming,et al."The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models".PHARMACOGENOMICS JOURNAL .增刊: S(2010):S5-S16.
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