| The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models | |
| Shi, Leming; Campbell, Gregory; Jones, Wendell D.; Oberthuer, Andre; Thomas, Russell S.; Paules, Richard S.; Fielden, Mark; Barlogie, Bart; Chen, Weijie; Du, Pan; Fischer, Matthias; Furlanello, Cesare; Campagne, Fabien; Wen, Zhining; Walker, Stephen J.; Su, Zhenqiang; Chu, Tzu-Ming; Goodsaid, Federico M.; Pusztai, Lajos; Shaughnessy, John D., Jr.; Shi, LM | |
| 2010-10 | |
| Source Publication | PHARMACOGENOMICS JOURNAL
 |
| Issue | 增刊: SPages:S5-S16 |
| Abstract | Gene expression data from microarrays are being applied to predict preclinical and clinical endpoints, but the reliability of these predictions has not been established In the MAQC II project, 36 independent teams analyzed six microarray data sets to generate predictive models for classifying a sample with respect to one of 13 endpoints indicative of lung or liver toxicity in rodents, or of breast cancer, multiple myeloma or neuroblastoma in humans In total, >30,000 models were built using many combinations of analytical methods The teams generated predictive models without knowing the biological meaning of some of the endpoints and, to mimic clinical reality, tested the models on data that had not been used for training We found that model performance depended largely on the endpoint and team proficiency and that different approaches generated models of similar performance The conclusions and recommendations from MAQC-II should be useful for regulatory agencies, study committees and independent investigators that evaluate methods for global gene expression analysis |
| Keyword | Gene-expression Data Control Maqc Project Published Microarray Follicular Lymphoma Dna Microarrays Breast-cancer One-color Performance Platforms Classification |
| Indexed By | SCI |
| Language | 英语 |
| Document Type | 期刊论文 |
| Version | 出版稿 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/5706 |
| Collection | 多相复杂系统国家重点实验室 |
| Corresponding Author | Shi, LM |
| Recommended Citation GB/T 7714 | Shi, Leming,Campbell, Gregory,Jones, Wendell D.,et al. The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models[J]. PHARMACOGENOMICS JOURNAL,2010(增刊: S):S5-S16. |
| APA | Shi, Leming.,Campbell, Gregory.,Jones, Wendell D..,Oberthuer, Andre.,Thomas, Russell S..,...&Shi, LM.(2010).The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models.PHARMACOGENOMICS JOURNAL(增刊: S),S5-S16. |
| MLA | Shi, Leming,et al."The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models".PHARMACOGENOMICS JOURNAL .增刊: S(2010):S5-S16. |
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| File Name/Size | DocType | Version | Access | License | ||
| 20131113-1142-复件 nbt（1151KB） | 限制开放 | CC BY-NC-SA | Application Full Text | |||
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