CAS OpenIR  > 湿法冶金清洁生产技术国家工程实验室
Molecular interaction between europium decatungstate and histone H1 and its application as a novel biological labeling agent
Zheng, Li1,2,5; Gu, Zhanjun3; Ma, Ying2; Zhang, Guangjin1; Yao, Jiannian2; Keita, Bineta4; Nadjo, Louis4; Zhang, GJ
2010-09-01
Source PublicationJOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
ISSN0949-8257
Volume15Issue:7Pages:1079-1085
AbstractPolyoxometalates (POMs) show promising biological activities, but the mechanism of potential therapeutic effects remains to be elucidated at a molecular level. As a step toward the elucidation of the mechanistic pathways governing the bioactivity of POMs, the interaction between Eu-containing decatungstate [EuW(10)O(36)](9-) (EuW10) and histone H1 has been studied. Fluorescence/luminescence analysis showed the existence of a strong interaction between EuW10 and histone H1. This interaction has key effects both on the luminescence of EuW10 and on the structure of histone H1. A gradual and intense enhancement of EuW10 luminescence was observed upon addition of increasing concentrations of histone H1. Circular dichroism investigations indicated that the binding of EuW10 significantly alters the secondary structure of histone H1. The present work is meaningful in finding novel labeling agents for fluorescence/luminescence or solid-state bioimaging.
KeywordLanthanide Polyoxometalates Histone H1 Luminescence Fluorescence Molecular Interaction Biolabel
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
DOI10.1007/s00775-010-0667-5
Indexed BySCI
Language英语
WOS KeywordHUMAN SERUM-ALBUMIN ; SEMICONDUCTOR QUANTUM DOTS ; POLYOXOMETALATE ; RECOGNITION ; ANTIBODIES ; LIPOSOMES ; BINDING ; PROTEIN ; DNA
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Inorganic & Nuclear
WOS IDWOS:000281597900009
Citation statistics
Cited Times:23[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.ipe.ac.cn/handle/122111/5719
Collection湿法冶金清洁生产技术国家工程实验室
Corresponding AuthorZhang, GJ
Affiliation1.Chinese Acad Sci, Key Lab Green Proc Engn, Inst Proc Engn, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Key Lab Photochem, Inst Chem, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Key Lab Biomed Effects Nanomat & Nanosafety, Inst High Energy Phys, Beijing 100049, Peoples R China
4.Univ Paris 11, Chim Phys Lab, CNRS, UMR 8000, F-91405 Orsay, France
5.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China
Recommended Citation
GB/T 7714
Zheng, Li,Gu, Zhanjun,Ma, Ying,et al. Molecular interaction between europium decatungstate and histone H1 and its application as a novel biological labeling agent[J]. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY,2010,15(7):1079-1085.
APA Zheng, Li.,Gu, Zhanjun.,Ma, Ying.,Zhang, Guangjin.,Yao, Jiannian.,...&Zhang, GJ.(2010).Molecular interaction between europium decatungstate and histone H1 and its application as a novel biological labeling agent.JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY,15(7),1079-1085.
MLA Zheng, Li,et al."Molecular interaction between europium decatungstate and histone H1 and its application as a novel biological labeling agent".JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY 15.7(2010):1079-1085.
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