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Microwave-enhanced dehydration and solvent washing purification of penicillin G sulfoxide
Alternative TitleInt. J. Pharm.
Pan, XJ; Liu, HZ; An, ZT; Wang, J; Niu, GG
2001-06-04
Source PublicationINTERNATIONAL JOURNAL OF PHARMACEUTICS
ISSN0378-5173
Volume220Issue:1-2Pages:33-41
AbstractIn the present study, a new microwave-enhanced dehydration and solvent washing purification of penicillin G sulfoxide technique has been developed. The results show that microwave irradiation can dehydrate penicillin G sulfoxide from a water content of 14-26 to below 0.5% in 40-60 min in N-2 or air. After washing with ethyl acetate to remove impurities and residual water, the penicillin G sulfoxide can be used to synthesize cephalosporanic acid. The recovery of cephalosporanic acid was equal to and the purity of cephalosporanic acid was higher by 2% than that of the current dehydration technique. FTIR spectroscopy was used to study the process of microwave-enhanced dehydration and solvent washing purification of penicillin G sulfoxide. (C) 2001 Elsevier Science B.V. All rights reserved.; In the present study, a new microwave-enhanced dehydration and solvent washing purification of penicillin G sulfoxide technique has been developed. The results show that microwave irradiation can dehydrate penicillin G sulfoxide from a water content of 14-26 to below 0.5% in 40-60 min in N-2 or air. After washing with ethyl acetate to remove impurities and residual water, the penicillin G sulfoxide can be used to synthesize cephalosporanic acid. The recovery of cephalosporanic acid was equal to and the purity of cephalosporanic acid was higher by 2% than that of the current dehydration technique. FTIR spectroscopy was used to study the process of microwave-enhanced dehydration and solvent washing purification of penicillin G sulfoxide. (C) 2001 Elsevier Science B.V. All rights reserved.
KeywordPenicillin g Sulfoxide Dehydration Microwave Enhanced Washing Ftir Spectroscopy
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
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Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000169184700004
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.ipe.ac.cn/handle/122111/5763
Collection研究所(批量导入)
AffiliationChinese Acad Sci, State Key Lab Biochem Engn, Inst Chem Met, Young Sci Lab Separat Sci & Engn, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Pan, XJ,Liu, HZ,An, ZT,et al. Microwave-enhanced dehydration and solvent washing purification of penicillin G sulfoxide[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2001,220(1-2):33-41.
APA Pan, XJ,Liu, HZ,An, ZT,Wang, J,&Niu, GG.(2001).Microwave-enhanced dehydration and solvent washing purification of penicillin G sulfoxide.INTERNATIONAL JOURNAL OF PHARMACEUTICS,220(1-2),33-41.
MLA Pan, XJ,et al."Microwave-enhanced dehydration and solvent washing purification of penicillin G sulfoxide".INTERNATIONAL JOURNAL OF PHARMACEUTICS 220.1-2(2001):33-41.
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