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Multipulse feed strategy for glycerol fed-batch fermentation - A steady-state nonlinear optimization approach
Alternative TitleAppl. Biochem. Biotechnol.
Xie, DM; Liu, DH; Zhu, HL; Liu, TZ
2001-08-01
Source PublicationAPPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
ISSN0273-2289
Volume95Issue:2Pages:103-112
AbstractDuring glycerol fed-batch fermentation, the process could be divided into multiple equal subintervals, and the feed operation was performed in pulse form at the start of each subinterval. Based on the macrokinetic models, the multipulse feed strategy for both glucose and corn steep slurry was determined by a general nonlinear optimization approach to maximize the final glycerol productivity and still control the residual glucose at a low concentration. The experimental results in a 600-mL Airlift Loop Reactor showed that the tested data with this strategy agreed well with the corresponding model prediction, and that the feed mode with nonlinear optimization could improve the glycerol productivity significantly compared with those determined just by limited experimental optimization in previous studies.; During glycerol fed-batch fermentation, the process could be divided into multiple equal subintervals, and the feed operation was performed in pulse form at the start of each subinterval. Based on the macrokinetic models, the multipulse feed strategy for both glucose and corn steep slurry was determined by a general nonlinear optimization approach to maximize the final glycerol productivity and still control the residual glucose at a low concentration. The experimental results in a 600-mL Airlift Loop Reactor showed that the tested data with this strategy agreed well with the corresponding model prediction, and that the feed mode with nonlinear optimization could improve the glycerol productivity significantly compared with those determined just by limited experimental optimization in previous studies.
KeywordGlycerol Multipulse Feed Fed-batch Fermentation Nonlinear Optimization
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
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Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Biotechnology & Applied Microbiology
WOS SubjectBiochemistry & Molecular Biology ; Biotechnology & Applied Microbiology
WOS IDWOS:000171548200004
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Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.ipe.ac.cn/handle/122111/5766
Collection研究所(批量导入)
Affiliation1.Tsing Hua Univ, Dept Chem Engn, Inst Appl Chem, Beijing 100084, Peoples R China
2.Chinese Acad Sci, Inst Chem Met, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Xie, DM,Liu, DH,Zhu, HL,et al. Multipulse feed strategy for glycerol fed-batch fermentation - A steady-state nonlinear optimization approach[J]. APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY,2001,95(2):103-112.
APA Xie, DM,Liu, DH,Zhu, HL,&Liu, TZ.(2001).Multipulse feed strategy for glycerol fed-batch fermentation - A steady-state nonlinear optimization approach.APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY,95(2),103-112.
MLA Xie, DM,et al."Multipulse feed strategy for glycerol fed-batch fermentation - A steady-state nonlinear optimization approach".APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY 95.2(2001):103-112.
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