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Chemically modified konjac glucomannan with high colloid osmotic pressure: Physiological evaluation in a rabbit model as a plasma substitute
Li, Suping1,2; Hu, Tao1; Chen, Yali1; Wang, Xianwei3; Liu, Tao1,2; Ma, Guanghui1; Su, Zhiguo1; Su, ZG
2010-08-01
Source PublicationGLYCOBIOLOGY
ISSN0959-6658
Volume20Issue:8Pages:950-958
AbstractCarboxylmethylated konjac glucomannan (CKGM) is a carboxylmethylated polymer of mannose and glucose that is derived from the plant Amorphophallus konjac cultivated in East Asia. The CKGM solution had a high volume-expanding efficacy and was evaluated as a plasma substitute in the present study. Ameliorative hemorrhagic shock rabbits were used as the model animals. The in vivo hemodynamic and hemorheologic properties, including blood pressure, blood viscosity, hematocrit, erythrocyte deformation index and erythrocyte aggregation index, were measured in animals treated in the CKGM solution. The in vitro colloid osmotic pressure (COP) of the CKGM solution was measured to estimate its plasma-expanding efficacy. These parameters of the CKGM-treated group were compared with groups exposed to four other treatments: human serum albumin (HSA), hydroxyethyl starch (HES), polygeline and normal saline. The CKGM solution showed an exceptionally higher COP than other therapy solutions. For example, the COP of 1% (weight in volume [w/v]) CKGM solution is comparable to those of 6% (w/v) HES solution and 5% (w/v) HSA solution. Accordingly, the CKGM solution can be transfused in a much lower dosage while maintaining its plasma-expanding efficacy. The CKGM-treated group showed an improved intravascular persistence and good hemodynamic and hemorheological properties. Biopsy analysis suggested no organ dysfunction in the group treated in CKGM solution. Moreover, the high plasma-expanding efficacy and inexpensive availability of the CKGM solution may facilitate its clinical application as a potential plasma substitute.
KeywordCarboxylmethylation Colloid Osmotic Pressure Konjac Glucomannan Plasma Substitute
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1093/glycob/cwq050
Indexed BySCI
Language英语
WOS KeywordHYDROXYETHYL STARCH ; FLUID RESUSCITATION ; MOLECULAR-WEIGHT ; SEPTIC SHOCK ; BLOOD-COAGULATION ; HEMORRHAGIC-SHOCK ; SEVERE SEPSIS ; SALINE ; REPLACEMENT ; GELATIN
WOS Research AreaBiochemistry & Molecular Biology
WOS SubjectBiochemistry & Molecular Biology
WOS IDWOS:000279469900002
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.ipe.ac.cn/handle/122111/5845
Collection生化工程国家重点实验室
Corresponding AuthorSu, ZG
Affiliation1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100190, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Biophys, Sch Basic Med Sci,Hemorheol ctr, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Li, Suping,Hu, Tao,Chen, Yali,et al. Chemically modified konjac glucomannan with high colloid osmotic pressure: Physiological evaluation in a rabbit model as a plasma substitute[J]. GLYCOBIOLOGY,2010,20(8):950-958.
APA Li, Suping.,Hu, Tao.,Chen, Yali.,Wang, Xianwei.,Liu, Tao.,...&Su, ZG.(2010).Chemically modified konjac glucomannan with high colloid osmotic pressure: Physiological evaluation in a rabbit model as a plasma substitute.GLYCOBIOLOGY,20(8),950-958.
MLA Li, Suping,et al."Chemically modified konjac glucomannan with high colloid osmotic pressure: Physiological evaluation in a rabbit model as a plasma substitute".GLYCOBIOLOGY 20.8(2010):950-958.
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