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Candida rugosa lipase catalyzed esterification of racemic ibuprofen with butanol: racemization of R-ibuprofen and chemical hydrolysis of S-ester formed
Alternative TitleBiotechnol. Lett.
Xie, YC; Liu, HZ; Chen, JY
1998-05-01
Source PublicationBIOTECHNOLOGY LETTERS
ISSN0141-5492
Volume20Issue:5Pages:455-458
AbstractThe chemical treatment of products obtained from Candida rugosa lipase catalyzed enantioselective esterification of racemic ibuprofen with n-butanol in isooctane was studied. After a complete separation of the unreacted R-ibuprofen from the S-ester formed, the R-ibuprofen was racemized and the S-ester was chemically hydrolyzed to S-ibuprofen with the same enantiomeric excess as that of the ester before hydrolysis. A cyclic process of preparing S-ibuprofen from its racemate with lipase catalysis in organic solvent is therefore feasible.; The chemical treatment of products obtained from Candida rugosa lipase catalyzed enantioselective esterification of racemic ibuprofen with n-butanol in isooctane was studied. After a complete separation of the unreacted R-ibuprofen from the S-ester formed, the R-ibuprofen was racemized and the S-ester was chemically hydrolyzed to S-ibuprofen with the same enantiomeric excess as that of the ester before hydrolysis. A cyclic process of preparing S-ibuprofen from its racemate with lipase catalysis in organic solvent is therefore feasible.
KeywordOrganic-solvents Drugs
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
URL查看原文
Indexed BySCI
Language英语
WOS KeywordORGANIC-SOLVENTS ; DRUGS
WOS Research AreaBiotechnology & Applied Microbiology
WOS SubjectBiotechnology & Applied Microbiology
WOS IDWOS:000074917800004
Citation statistics
Cited Times:33[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.ipe.ac.cn/handle/122111/5869
Collection研究所(批量导入)
AffiliationChinese Acad Sci, Inst Chem Met, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Xie, YC,Liu, HZ,Chen, JY. Candida rugosa lipase catalyzed esterification of racemic ibuprofen with butanol: racemization of R-ibuprofen and chemical hydrolysis of S-ester formed[J]. BIOTECHNOLOGY LETTERS,1998,20(5):455-458.
APA Xie, YC,Liu, HZ,&Chen, JY.(1998).Candida rugosa lipase catalyzed esterification of racemic ibuprofen with butanol: racemization of R-ibuprofen and chemical hydrolysis of S-ester formed.BIOTECHNOLOGY LETTERS,20(5),455-458.
MLA Xie, YC,et al."Candida rugosa lipase catalyzed esterification of racemic ibuprofen with butanol: racemization of R-ibuprofen and chemical hydrolysis of S-ester formed".BIOTECHNOLOGY LETTERS 20.5(1998):455-458.
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