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Candida rugosa lipase catalyzed esterification of racemic ibuprofen with butanol: racemization of R-ibuprofen and chemical hydrolysis of S-ester formed | |
Alternative Title | Biotechnol. Lett. |
Xie, YC; Liu, HZ; Chen, JY | |
1998-05-01 | |
Source Publication | BIOTECHNOLOGY LETTERS
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ISSN | 0141-5492 |
Volume | 20Issue:5Pages:455-458 |
Abstract | The chemical treatment of products obtained from Candida rugosa lipase catalyzed enantioselective esterification of racemic ibuprofen with n-butanol in isooctane was studied. After a complete separation of the unreacted R-ibuprofen from the S-ester formed, the R-ibuprofen was racemized and the S-ester was chemically hydrolyzed to S-ibuprofen with the same enantiomeric excess as that of the ester before hydrolysis. A cyclic process of preparing S-ibuprofen from its racemate with lipase catalysis in organic solvent is therefore feasible.; The chemical treatment of products obtained from Candida rugosa lipase catalyzed enantioselective esterification of racemic ibuprofen with n-butanol in isooctane was studied. After a complete separation of the unreacted R-ibuprofen from the S-ester formed, the R-ibuprofen was racemized and the S-ester was chemically hydrolyzed to S-ibuprofen with the same enantiomeric excess as that of the ester before hydrolysis. A cyclic process of preparing S-ibuprofen from its racemate with lipase catalysis in organic solvent is therefore feasible. |
Keyword | Organic-solvents Drugs |
Subtype | Article |
WOS Headings | Science & Technology ; Life Sciences & Biomedicine |
URL | 查看原文 |
Indexed By | SCI |
Language | 英语 |
WOS Keyword | ORGANIC-SOLVENTS ; DRUGS |
WOS Research Area | Biotechnology & Applied Microbiology |
WOS Subject | Biotechnology & Applied Microbiology |
WOS ID | WOS:000074917800004 |
Citation statistics | |
Document Type | 期刊论文 |
Version | 出版稿 |
Identifier | http://ir.ipe.ac.cn/handle/122111/5869 |
Collection | 研究所(批量导入) |
Affiliation | Chinese Acad Sci, Inst Chem Met, Beijing 100080, Peoples R China |
Recommended Citation GB/T 7714 | Xie, YC,Liu, HZ,Chen, JY. Candida rugosa lipase catalyzed esterification of racemic ibuprofen with butanol: racemization of R-ibuprofen and chemical hydrolysis of S-ester formed[J]. BIOTECHNOLOGY LETTERS,1998,20(5):455-458. |
APA | Xie, YC,Liu, HZ,&Chen, JY.(1998).Candida rugosa lipase catalyzed esterification of racemic ibuprofen with butanol: racemization of R-ibuprofen and chemical hydrolysis of S-ester formed.BIOTECHNOLOGY LETTERS,20(5),455-458. |
MLA | Xie, YC,et al."Candida rugosa lipase catalyzed esterification of racemic ibuprofen with butanol: racemization of R-ibuprofen and chemical hydrolysis of S-ester formed".BIOTECHNOLOGY LETTERS 20.5(1998):455-458. |
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