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| Candida rugosa lipase catalyzed esterification of racemic ibuprofen with butanol: racemization of R-ibuprofen and chemical hydrolysis of S-ester formed | |
| Alternative Title | Biotechnol. Lett. |
| Xie, YC; Liu, HZ; Chen, JY | |
| 1998-05-01 | |
| Source Publication | BIOTECHNOLOGY LETTERS
 |
| ISSN | 0141-5492 |
| Volume | 20Issue:5Pages:455-458 |
| Abstract | The chemical treatment of products obtained from Candida rugosa lipase catalyzed enantioselective esterification of racemic ibuprofen with n-butanol in isooctane was studied. After a complete separation of the unreacted R-ibuprofen from the S-ester formed, the R-ibuprofen was racemized and the S-ester was chemically hydrolyzed to S-ibuprofen with the same enantiomeric excess as that of the ester before hydrolysis. A cyclic process of preparing S-ibuprofen from its racemate with lipase catalysis in organic solvent is therefore feasible.; The chemical treatment of products obtained from Candida rugosa lipase catalyzed enantioselective esterification of racemic ibuprofen with n-butanol in isooctane was studied. After a complete separation of the unreacted R-ibuprofen from the S-ester formed, the R-ibuprofen was racemized and the S-ester was chemically hydrolyzed to S-ibuprofen with the same enantiomeric excess as that of the ester before hydrolysis. A cyclic process of preparing S-ibuprofen from its racemate with lipase catalysis in organic solvent is therefore feasible. |
| Keyword | Organic-solvents Drugs |
| Subtype | Article |
| WOS Headings | Science & Technology ; Life Sciences & Biomedicine |
| URL | 查看原文 |
| Indexed By | SCI |
| Language | 英语 |
| WOS Keyword | ORGANIC-SOLVENTS ; DRUGS |
| WOS Research Area | Biotechnology & Applied Microbiology |
| WOS Subject | Biotechnology & Applied Microbiology |
| WOS ID | WOS:000074917800004 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Version | 出版稿 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/5869 |
| Collection | 研究所（批量导入） |
| Affiliation | Chinese Acad Sci, Inst Chem Met, Beijing 100080, Peoples R China |
| Recommended Citation GB/T 7714 | Xie, YC,Liu, HZ,Chen, JY. Candida rugosa lipase catalyzed esterification of racemic ibuprofen with butanol: racemization of R-ibuprofen and chemical hydrolysis of S-ester formed[J]. BIOTECHNOLOGY LETTERS,1998,20(5):455-458. |
| APA | Xie, YC,Liu, HZ,&Chen, JY.(1998).Candida rugosa lipase catalyzed esterification of racemic ibuprofen with butanol: racemization of R-ibuprofen and chemical hydrolysis of S-ester formed.BIOTECHNOLOGY LETTERS,20(5),455-458. |
| MLA | Xie, YC,et al."Candida rugosa lipase catalyzed esterification of racemic ibuprofen with butanol: racemization of R-ibuprofen and chemical hydrolysis of S-ester formed".BIOTECHNOLOGY LETTERS 20.5(1998):455-458. |
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| File Name/Size | DocType | Version | Access | License | ||
| Candida rugosa lipas（279KB） | 限制开放 | CC BY-NC-SA | Application Full Text | |||
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