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Design, synthesis and structure-activity relationships of novel ALS inhibitors
Alternative TitlePest Manag. Sci.
Ren, TR; Yang, HW; Gao, X; Yang, XL; Zhou, JJ; Cheng, FH
2000-03-01
Source PublicationPEST MANAGEMENT SCIENCE
ISSN1526-498X
Volume56Issue:3Pages:218-226
AbstractThe paper describes the biophore models of sulfonylurea, imidazolinone, triazolopyrimidinesulfonamide and 5-pyrimidyltriazolo-3-sulfonamides established by the Apex-3D method. A series of N-phenylsulfonyl-N'-(thiadiazol-2-yl) oxamides and three types of triazolopyrimidinesulfonamide were synthesised and their herbicidal activities determined to assess the validity of the model. In general, the model gave useful leads to activity, although the actual level was not always predicted accurately. In only a few cases did compounds predicted as being active prove to be inactive in the bioassay, and compounds with little or no activity were clearly indicated, As a result of this work, the compound N,N'-[1-(5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidin-2-ylthio)butane-2,3-di-imino]bis(2-chlorobenzenesulfonamide) was selected as showing good activity against a range of species, and will be used as a lead for further development, (C) 2000 Society of Chemical Industry.; The paper describes the biophore models of sulfonylurea, imidazolinone, triazolopyrimidinesulfonamide and 5-pyrimidyltriazolo-3-sulfonamides established by the Apex-3D method. A series of N-phenylsulfonyl-N'-(thiadiazol-2-yl) oxamides and three types of triazolopyrimidinesulfonamide were synthesised and their herbicidal activities determined to assess the validity of the model. In general, the model gave useful leads to activity, although the actual level was not always predicted accurately. In only a few cases did compounds predicted as being active prove to be inactive in the bioassay, and compounds with little or no activity were clearly indicated, As a result of this work, the compound N,N'-[1-(5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidin-2-ylthio)butane-2,3-di-imino]bis(2-chlorobenzenesulfonamide) was selected as showing good activity against a range of species, and will be used as a lead for further development, (C) 2000 Society of Chemical Industry.
KeywordMolecular Modelling Apex-3d Herbicides Als Inhibitors
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
URL查看原文
Indexed BySCI
Language英语
WOS KeywordACETOLACTATE SYNTHASE ; DERIVATIVES ; SITE
WOS Research AreaAgriculture ; Entomology
WOS SubjectAgronomy ; Entomology
WOS IDWOS:000086542000002
Citation statistics
Cited Times:22[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.ipe.ac.cn/handle/122111/5886
Collection研究所(批量导入)
Affiliation1.Chinese Acad Sci, Inst Chem Met, Lab Comp Chem, Beijing 100080, Peoples R China
2.China Agr Univ, Dept Appl Chem, Beijing 100094, Peoples R China
Recommended Citation
GB/T 7714
Ren, TR,Yang, HW,Gao, X,et al. Design, synthesis and structure-activity relationships of novel ALS inhibitors[J]. PEST MANAGEMENT SCIENCE,2000,56(3):218-226.
APA Ren, TR,Yang, HW,Gao, X,Yang, XL,Zhou, JJ,&Cheng, FH.(2000).Design, synthesis and structure-activity relationships of novel ALS inhibitors.PEST MANAGEMENT SCIENCE,56(3),218-226.
MLA Ren, TR,et al."Design, synthesis and structure-activity relationships of novel ALS inhibitors".PEST MANAGEMENT SCIENCE 56.3(2000):218-226.
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