Knowledge Management System Of Institute of process engineering,CAS
Kinetics of base catalyzed racemization of ibuprofen enantiomers | |
Alternative Title | Int. J. Pharm. |
Xie, YC; Liu, HZ; Chen, JY | |
2000-02-25 | |
Source Publication | INTERNATIONAL JOURNAL OF PHARMACEUTICS
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ISSN | 0378-5173 |
Volume | 196Issue:1Pages:21-26 |
Abstract | The kinetics of base catalyzed racemization of ibuprofen enantiomers has been studied in DMSO-water mixed medium. The dynamic equilibrium rate of keto-enol tautomerism leading to racemization of ibuprofen enantiomers, is proportional to the concentrations of base catalyst and substrate. A kinetic model capable of predicting the time course of racemization. under different base and substrate concentrations, is, established and experimentally verified. (C) 2000 Elsevier Science B.V. All rights reserved.; The kinetics of base catalyzed racemization of ibuprofen enantiomers has been studied in DMSO-water mixed medium. The dynamic equilibrium rate of keto-enol tautomerism leading to racemization of ibuprofen enantiomers, is proportional to the concentrations of base catalyst and substrate. A kinetic model capable of predicting the time course of racemization. under different base and substrate concentrations, is, established and experimentally verified. (C) 2000 Elsevier Science B.V. All rights reserved. |
Keyword | Ibuprofen Enantiomer Resolution Racemization Kinetics Base Catalysis |
Subtype | Article |
WOS Headings | Science & Technology ; Life Sciences & Biomedicine |
URL | 查看原文 |
Indexed By | SCI |
Language | 英语 |
WOS Keyword | RACEMIC IBUPROFEN ; ESTERIFICATION ; SOLVENT ; LIPASE ; DRUGS ; ENOL |
WOS Research Area | Pharmacology & Pharmacy |
WOS Subject | Pharmacology & Pharmacy |
WOS ID | WOS:000085614600003 |
Citation statistics | |
Document Type | 期刊论文 |
Version | 出版稿 |
Identifier | http://ir.ipe.ac.cn/handle/122111/5975 |
Collection | 研究所(批量导入) |
Affiliation | Chinese Acad Sci, Inst Chem Met, Beijing 100080, Peoples R China |
Recommended Citation GB/T 7714 | Xie, YC,Liu, HZ,Chen, JY. Kinetics of base catalyzed racemization of ibuprofen enantiomers[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2000,196(1):21-26. |
APA | Xie, YC,Liu, HZ,&Chen, JY.(2000).Kinetics of base catalyzed racemization of ibuprofen enantiomers.INTERNATIONAL JOURNAL OF PHARMACEUTICS,196(1),21-26. |
MLA | Xie, YC,et al."Kinetics of base catalyzed racemization of ibuprofen enantiomers".INTERNATIONAL JOURNAL OF PHARMACEUTICS 196.1(2000):21-26. |
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Kinetics of base cat(105KB) | 限制开放 | CC BY-NC-SA | Application Full Text |
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