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Kinetics of base catalyzed racemization of ibuprofen enantiomers
Alternative TitleInt. J. Pharm.
Xie, YC; Liu, HZ; Chen, JY
2000-02-25
Source PublicationINTERNATIONAL JOURNAL OF PHARMACEUTICS
ISSN0378-5173
Volume196Issue:1Pages:21-26
AbstractThe kinetics of base catalyzed racemization of ibuprofen enantiomers has been studied in DMSO-water mixed medium. The dynamic equilibrium rate of keto-enol tautomerism leading to racemization of ibuprofen enantiomers, is proportional to the concentrations of base catalyst and substrate. A kinetic model capable of predicting the time course of racemization. under different base and substrate concentrations, is, established and experimentally verified. (C) 2000 Elsevier Science B.V. All rights reserved.; The kinetics of base catalyzed racemization of ibuprofen enantiomers has been studied in DMSO-water mixed medium. The dynamic equilibrium rate of keto-enol tautomerism leading to racemization of ibuprofen enantiomers, is proportional to the concentrations of base catalyst and substrate. A kinetic model capable of predicting the time course of racemization. under different base and substrate concentrations, is, established and experimentally verified. (C) 2000 Elsevier Science B.V. All rights reserved.
KeywordIbuprofen Enantiomer Resolution Racemization Kinetics Base Catalysis
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
URL查看原文
Indexed BySCI
Language英语
WOS KeywordRACEMIC IBUPROFEN ; ESTERIFICATION ; SOLVENT ; LIPASE ; DRUGS ; ENOL
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000085614600003
Citation statistics
Cited Times:51[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.ipe.ac.cn/handle/122111/5975
Collection研究所(批量导入)
AffiliationChinese Acad Sci, Inst Chem Met, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Xie, YC,Liu, HZ,Chen, JY. Kinetics of base catalyzed racemization of ibuprofen enantiomers[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2000,196(1):21-26.
APA Xie, YC,Liu, HZ,&Chen, JY.(2000).Kinetics of base catalyzed racemization of ibuprofen enantiomers.INTERNATIONAL JOURNAL OF PHARMACEUTICS,196(1),21-26.
MLA Xie, YC,et al."Kinetics of base catalyzed racemization of ibuprofen enantiomers".INTERNATIONAL JOURNAL OF PHARMACEUTICS 196.1(2000):21-26.
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