Knowledge Management System Of Institute of process engineering,CAS
| Kinetics of base catalyzed racemization of ibuprofen enantiomers | |
| Alternative Title | Int. J. Pharm. |
| Xie, YC; Liu, HZ; Chen, JY | |
| 2000-02-25 | |
| Source Publication | INTERNATIONAL JOURNAL OF PHARMACEUTICS
 |
| ISSN | 0378-5173 |
| Volume | 196Issue:1Pages:21-26 |
| Abstract | The kinetics of base catalyzed racemization of ibuprofen enantiomers has been studied in DMSO-water mixed medium. The dynamic equilibrium rate of keto-enol tautomerism leading to racemization of ibuprofen enantiomers, is proportional to the concentrations of base catalyst and substrate. A kinetic model capable of predicting the time course of racemization. under different base and substrate concentrations, is, established and experimentally verified. (C) 2000 Elsevier Science B.V. All rights reserved.; The kinetics of base catalyzed racemization of ibuprofen enantiomers has been studied in DMSO-water mixed medium. The dynamic equilibrium rate of keto-enol tautomerism leading to racemization of ibuprofen enantiomers, is proportional to the concentrations of base catalyst and substrate. A kinetic model capable of predicting the time course of racemization. under different base and substrate concentrations, is, established and experimentally verified. (C) 2000 Elsevier Science B.V. All rights reserved. |
| Keyword | Ibuprofen Enantiomer Resolution Racemization Kinetics Base Catalysis |
| Subtype | Article |
| WOS Headings | Science & Technology ; Life Sciences & Biomedicine |
| URL | 查看原文 |
| Indexed By | SCI |
| Language | 英语 |
| WOS Keyword | RACEMIC IBUPROFEN ; ESTERIFICATION ; SOLVENT ; LIPASE ; DRUGS ; ENOL |
| WOS Research Area | Pharmacology & Pharmacy |
| WOS Subject | Pharmacology & Pharmacy |
| WOS ID | WOS:000085614600003 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Version | 出版稿 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/5975 |
| Collection | 研究所（批量导入） |
| Affiliation | Chinese Acad Sci, Inst Chem Met, Beijing 100080, Peoples R China |
| Recommended Citation GB/T 7714 | Xie, YC,Liu, HZ,Chen, JY. Kinetics of base catalyzed racemization of ibuprofen enantiomers[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2000,196(1):21-26. |
| APA | Xie, YC,Liu, HZ,&Chen, JY.(2000).Kinetics of base catalyzed racemization of ibuprofen enantiomers.INTERNATIONAL JOURNAL OF PHARMACEUTICS,196(1),21-26. |
| MLA | Xie, YC,et al."Kinetics of base catalyzed racemization of ibuprofen enantiomers".INTERNATIONAL JOURNAL OF PHARMACEUTICS 196.1(2000):21-26. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| Kinetics of base cat（105KB） | 限制开放 | CC BY-NC-SA | Application Full Text | |||
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