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Kinetics of lipase catalyzed enantioselective esterification of racemic ibuprofen in isooctane
Alternative TitleChin. J. Chem. Eng.
Xie, YC; Liu, HZ; Chen, JY
2000-03-01
Source PublicationCHINESE JOURNAL OF CHEMICAL ENGINEERING
ISSN1004-9541
Volume8Issue:1Pages:6-14
AbstractThe kinetics of Candida rugosa lipase catalyzed esterification of racemic ibuprofen with n-butanol in isooctane was studied. The kinetic study was carried out with the addition of 0.1% and 2% (by volume) of water for enzyme activation respectively when celite was added into isooctane for enzyme dispersion. The specific initial rate for S-ibuprofen can be fitted with the Ping Pong Pi Bi mechanism with dead-end competitive inhibition by the alcohol. The time courses of the enantioselective esterification of the two ibuprofen enantiomers with different initial substrate concentrations and water contents were simulated with a model in which both effects of enzyme inactivation by long term reaction and reversed hydrolytic reaction under high water content were taken into consideration.; The kinetics of Candida rugosa lipase catalyzed esterification of racemic ibuprofen with n-butanol in isooctane was studied. The kinetic study was carried out with the addition of 0.1% and 2% (by volume) of water for enzyme activation respectively when celite was added into isooctane for enzyme dispersion. The specific initial rate for S-ibuprofen can be fitted with the Ping Pong Pi Bi mechanism with dead-end competitive inhibition by the alcohol. The time courses of the enantioselective esterification of the two ibuprofen enantiomers with different initial substrate concentrations and water contents were simulated with a model in which both effects of enzyme inactivation by long term reaction and reversed hydrolytic reaction under high water content were taken into consideration.
KeywordResolution Kinetics Lipase S-ibuprofen Water Content Organic Solvent Dispersant
SubtypeArticle
WOS HeadingsScience & Technology ; Technology
URL查看原文
Indexed BySCI
Language英语
WOS KeywordORGANIC-SOLVENTS ; WATER ACTIVITY ; ESTER PRODRUG ; THERMOSTABILITY ; RESOLUTION ; ENZYMES ; DRUGS
WOS Research AreaEngineering
WOS SubjectEngineering, Chemical
WOS IDWOS:000086195700002
Citation statistics
Document Type期刊论文
Version出版稿
Identifierhttp://ir.ipe.ac.cn/handle/122111/5978
Collection研究所(批量导入)
AffiliationChinese Acad Sci, Inst Chem Met, Young Scientist Lab Separat Sci & Engn, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Xie, YC,Liu, HZ,Chen, JY. Kinetics of lipase catalyzed enantioselective esterification of racemic ibuprofen in isooctane[J]. CHINESE JOURNAL OF CHEMICAL ENGINEERING,2000,8(1):6-14.
APA Xie, YC,Liu, HZ,&Chen, JY.(2000).Kinetics of lipase catalyzed enantioselective esterification of racemic ibuprofen in isooctane.CHINESE JOURNAL OF CHEMICAL ENGINEERING,8(1),6-14.
MLA Xie, YC,et al."Kinetics of lipase catalyzed enantioselective esterification of racemic ibuprofen in isooctane".CHINESE JOURNAL OF CHEMICAL ENGINEERING 8.1(2000):6-14.
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