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Recovery of taxol from the extract of Taxus cuspidate callus cultures with Al2O3 chromatography
Alternative TitleJ. Liq. Chromatogr. Relat. Technol.
Zhang, ZQ; Su, ZG
2000
Source PublicationJOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES
ISSN1082-6076
Volume23Issue:17Pages:2683-2693
AbstractIn this study, we reported a chromatographic protocol using C-18 silica gel phase and basic Al2O3 phase to research the creating and recovery of taxol from the extract of Taxus cuspidate callus cultures. With the cleaning up by basic Al2O3 chromatography, the content of taxol determined in our experiment was increased greatly. The main source of increasing taxol concentration was the isomerization of 7-epi-taxol to taxol; taxol could also be decomposed to baccatin III and 10-deacetylbaccatin III in the Al2O3 column. At the optimized conditions, the total recovery of taxol from the extract was more than 160%.; In this study, we reported a chromatographic protocol using C-18 silica gel phase and basic Al2O3 phase to research the creating and recovery of taxol from the extract of Taxus cuspidate callus cultures. With the cleaning up by basic Al2O3 chromatography, the content of taxol determined in our experiment was increased greatly. The main source of increasing taxol concentration was the isomerization of 7-epi-taxol to taxol; taxol could also be decomposed to baccatin III and 10-deacetylbaccatin III in the Al2O3 column. At the optimized conditions, the total recovery of taxol from the extract was more than 160%.
KeywordLiquid-chromatography Taxanes Brevifolia
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
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Indexed BySCI
Language英语
WOS KeywordLIQUID-CHROMATOGRAPHY ; TAXANES ; BREVIFOLIA
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemical Research Methods ; Chemistry, Analytical
WOS IDWOS:000090063000006
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.ipe.ac.cn/handle/122111/6046
Collection研究所(批量导入)
AffiliationChinese Acad Sci, Inst Chem Met, State Key Lab Biochem Engn, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Zhang, ZQ,Su, ZG. Recovery of taxol from the extract of Taxus cuspidate callus cultures with Al2O3 chromatography[J]. JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES,2000,23(17):2683-2693.
APA Zhang, ZQ,&Su, ZG.(2000).Recovery of taxol from the extract of Taxus cuspidate callus cultures with Al2O3 chromatography.JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES,23(17),2683-2693.
MLA Zhang, ZQ,et al."Recovery of taxol from the extract of Taxus cuspidate callus cultures with Al2O3 chromatography".JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES 23.17(2000):2683-2693.
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