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A novel injectable chlorhexidine thermosensitive hydrogel for periodontal application: preparation, antibacterial activity and toxicity evaluation
Ji, Qiu Xia1; Zhao, Qing Sheng2,3; Deng, Jing1; Lue, Rui4; Ji, QX
2010-08-01
Source PublicationJOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
ISSN0957-4530
Volume21Issue:8Pages:2435-2442
AbstractThe aim of this paper was to evaluate the application potential of CS-HTCC/GP-0.1%Chx thermosensitive hydrogel which was synthesized using chitosan (CS), quaternized CS, and alpha,beta-glycerophosphate (alpha,beta-GP) loading with 0.1% chlorhexidine (Chx) (w/v) for periodontal treatment. An aqueous solution of CS-HTCC/GP-0.1%Chx was transformed into hydrogel at 6 min when the temperature was increased to 37A degrees C. The scan electron microscopy (SEM) image of the gel was a porous, loose and crosslinked network. In vitro, Chx released over 18 h from the CS-HTCC/GP thermosensitive hydrogel in artificial saliva pH 6.8. Release rate could be controlled through adjustment of alpha,beta-GP or Chx concentration. CS-HTCC/GP-0.1%Chx thermosensitive hydrogel exhibited excellent inhibitory activity against primary periodontal pathogens. CS-HTCC/GP-0.1%Chx thermosensitive hydrogel had no acute toxicity; the maximum tolerated dose in rats was 400 mg/ml. All results indicated that CS-HTCC/GP-0.1%Chx thermosensitive hydrogel is a strong candidate as a local drug delivery system for periodontal treatment.
KeywordSingle-species Biofilm In-vitro Quaternized Chitosan Adult Periodontitis Controlled-release Delivery System Trial Minocycline Gel Gluconate
SubtypeArticle
WOS HeadingsScience & Technology ; Technology
DOI10.1007/s10856-010-4098-1
Indexed BySCI ; ISTP
Language英语
WOS KeywordSINGLE-SPECIES BIOFILM ; IN-VITRO ; QUATERNIZED CHITOSAN ; ADULT PERIODONTITIS ; CONTROLLED-RELEASE ; DELIVERY SYSTEM ; TRIAL ; MINOCYCLINE ; GEL ; GLUCONATE
WOS Research AreaEngineering ; Materials Science
WOS SubjectEngineering, Biomedical ; Materials Science, Biomaterials
WOS IDWOS:000280814800023
Citation statistics
Cited Times:36[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.ipe.ac.cn/handle/122111/6109
Collection生化工程国家重点实验室
Corresponding AuthorJi, QX
Affiliation1.Qingdao Univ, Dept Stomatol, Affiliated Hosp, Coll Med, Qingdao 266001, Shandong, Peoples R China
2.Chinese Acad Sci, State Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100190, Peoples R China
4.Qingdao Univ, Lab Med Microbiol, Coll Med, Qingdao 266001, Shandong, Peoples R China
Recommended Citation
GB/T 7714
Ji, Qiu Xia,Zhao, Qing Sheng,Deng, Jing,et al. A novel injectable chlorhexidine thermosensitive hydrogel for periodontal application: preparation, antibacterial activity and toxicity evaluation[J]. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE,2010,21(8):2435-2442.
APA Ji, Qiu Xia,Zhao, Qing Sheng,Deng, Jing,Lue, Rui,&Ji, QX.(2010).A novel injectable chlorhexidine thermosensitive hydrogel for periodontal application: preparation, antibacterial activity and toxicity evaluation.JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE,21(8),2435-2442.
MLA Ji, Qiu Xia,et al."A novel injectable chlorhexidine thermosensitive hydrogel for periodontal application: preparation, antibacterial activity and toxicity evaluation".JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE 21.8(2010):2435-2442.
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