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Hypoglycaemic effect of comatin, an antidiabetic substance separated from Coprinus comatus broth, on alloxan-induced-diabetic rats
Ding, Zhongyang1,2,3; Lu, Yingjian1; Lu, Zhaoxin1; Lv, Fengxia1; Wang, Yuhong2,3; Bie, Xiaomei1; Wang, Feng4; Zhang, Kechang2,3; Lu, ZX
2010-07-01
Source PublicationFOOD CHEMISTRY
ISSN0308-8146
Volume121Issue:1Pages:39-43
AbstractComatin, an inhibitor of the non-enzymatic glycosylation (NEG) reaction, was isolated from Coprinus comatus fermentation broth by macroporous resin separation, followed by chromatographic purification using a C18 reversed-phase column. The compound was identified as 4,5-dihydroxy-2-methoxy-benzal-dehyde by high-resolution MS, IR, NMR and UV analyses. The hypoglycaemic effect of comatin, on both normal and alloxan-induced-diabetic rats, was investigated in the paper. The blood glucose concentration of normal rats treated by the comatin at 80 mg/kg body weight was reduced from 5.14 mM to 4.28 mM in 3 h. Also, the concentrations of fructosamine, triglycerides and total cholesterol in induced-diabetic rats were significantly decreased. These results indicated that comatin could maintain a low level of blood glucose and improve glucose tolerance. (C) 2009 Elsevier Ltd. All rights reserved.
KeywordCoprinus Comatus Non-enzymatic Glycosylation 4 Hypoglycaemic 5-dihydroxy-2-methoxy-benzaldehyde Alloxan
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences ; Life Sciences & Biomedicine
DOI10.1016/j.foodchem.2009.12.001
Indexed BySCI
Language英语
WOS KeywordIN-VITRO ; FRUITING BODIES ; GLYCATION ; MELLITUS ; INHIBITION ; MUSHROOM ; PRODUCTS ; EXTRACTS
WOS Research AreaChemistry ; Food Science & Technology ; Nutrition & Dietetics
WOS SubjectChemistry, Applied ; Food Science & Technology ; Nutrition & Dietetics
WOS IDWOS:000275360200005
Citation statistics
Cited Times:20[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.ipe.ac.cn/handle/122111/6122
Collection生化工程国家重点实验室
Corresponding AuthorLu, ZX
Affiliation1.Nanjing Agr Univ, Sch Food Sci & Technol, Nanjing 210095, Peoples R China
2.Jiangnam Univ, Minist Educ, Key Lab Ind Biotechnol, Wuxi 214122, Peoples R China
3.Jiangnam Univ, Sch Biotechnol, Wuxi 214122, Peoples R China
4.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Ding, Zhongyang,Lu, Yingjian,Lu, Zhaoxin,et al. Hypoglycaemic effect of comatin, an antidiabetic substance separated from Coprinus comatus broth, on alloxan-induced-diabetic rats[J]. FOOD CHEMISTRY,2010,121(1):39-43.
APA Ding, Zhongyang.,Lu, Yingjian.,Lu, Zhaoxin.,Lv, Fengxia.,Wang, Yuhong.,...&Lu, ZX.(2010).Hypoglycaemic effect of comatin, an antidiabetic substance separated from Coprinus comatus broth, on alloxan-induced-diabetic rats.FOOD CHEMISTRY,121(1),39-43.
MLA Ding, Zhongyang,et al."Hypoglycaemic effect of comatin, an antidiabetic substance separated from Coprinus comatus broth, on alloxan-induced-diabetic rats".FOOD CHEMISTRY 121.1(2010):39-43.
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