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Galactosylated nanocrystallites of insoluble anticancer drug for liver-targeting therapy: an in vitro evaluation
Wei, Wei1,2; Yue, Zhan-Guo1,2; Qu, Jian-Bo3; Yue, Hua1,2; Su, Zhi-Guo1; Ma, Guang-Hui1; Ma, GH
2010-06-01
Source PublicationNANOMEDICINE
ISSN1743-5889
Volume5Issue:4Pages:589-596
AbstractAim: Low solubility in water has become an intrinsic property of many anticancer drugs, which poses a hurdle in the translation from the bench to the clinic. In this study, we developed a facile method to prepare 10-hydroxycamptothecin (HCPT) nanocrystallites and testified their feasibility for liver-targeting therapy. Materials & methods: HCPT nanocrystallites were prepared under the soft template effect of galactosylated chitosan. The internalization profile, intracellular trafficking, drug activity and cell viability were evaluated by exposing these nanocrystallites to human hepatocellular carcinoma HepG2 cells. Results: Galactosylated chitosan located on the HCPT nanocrystallites not only stabilized the formulation in aqueous medium, but also enhanced the cellular internalization through an asialoglycoprotein receptor-mediated pathway. These nanocrystallites also exhibited the advantages of nuclear entry and active HCPT delivery, and consequently better anticancer cytotoxicity could be achieved. Conclusion: These data strongly support the superior properties of galactosylated HCPT nanocrystallites on liver-targeting therapy.
Keyword10-hydroxycamptothecin Anticancer Asialoglycoprotein Receptor Drug Delivery Nanocrystallites
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.2217/NNM.10.27
Indexed BySCI
Language英语
WOS KeywordNUCLEAR-LOCALIZATION SIGNAL ; WATER-SOLUBLE DRUGS ; PLASMID DNA ; CURRENT PERSPECTIVES ; CANCER-THERAPY ; DELIVERY ; CAMPTOTHECIN ; CHITOSAN ; CELLS ; PERMEABILITY
WOS Research AreaBiotechnology & Applied Microbiology ; Science & Technology - Other Topics
WOS SubjectBiotechnology & Applied Microbiology ; Nanoscience & Nanotechnology
WOS IDWOS:000278937100010
Citation statistics
Cited Times:46[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.ipe.ac.cn/handle/122111/6143
Collection生化工程国家重点实验室
Corresponding AuthorMa, GH
Affiliation1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
3.China Univ Petr, Ctr Bioengn & Biotechnol, Qingdao 266555, Peoples R China
Recommended Citation
GB/T 7714
Wei, Wei,Yue, Zhan-Guo,Qu, Jian-Bo,et al. Galactosylated nanocrystallites of insoluble anticancer drug for liver-targeting therapy: an in vitro evaluation[J]. NANOMEDICINE,2010,5(4):589-596.
APA Wei, Wei.,Yue, Zhan-Guo.,Qu, Jian-Bo.,Yue, Hua.,Su, Zhi-Guo.,...&Ma, GH.(2010).Galactosylated nanocrystallites of insoluble anticancer drug for liver-targeting therapy: an in vitro evaluation.NANOMEDICINE,5(4),589-596.
MLA Wei, Wei,et al."Galactosylated nanocrystallites of insoluble anticancer drug for liver-targeting therapy: an in vitro evaluation".NANOMEDICINE 5.4(2010):589-596.
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