CAS OpenIR  > 生化工程国家重点实验室
One step recovery of succinic acid from fermentation broths by crystallization
Li, Qiang1,2; Wang, Dan1,2; Wu, Yong2,3; Li, Wangliang1; Zhang, Yunjian4; Xing, Jianmin1; Su, Zhiguo1; Xing, JM
AbstractSuccinic acid is a valuable four-carbon platform chemical with wide applications in many fields. One step recovery of the desired product succinic acid crystal from the fermentation broths was studied for the first time. In a fed batch fermentation by Actinobacillus succinogenes BE-1, the final concentrations of succinic acid, formic acid, lactic acid and acetic acid in the bioreactor reached 97.8 g/L, 23.5 g/L, 5.1 g/L and 17.4 g/L, respectively. These organic acids have different proportions of dissociated and undissociated forms at different pH values, and the solubility of these forms of acid is different substantially. When the pH value of the fermentation broth was controlled less than 2.0, crystallization of succinic acid could be carried out at 4 degrees C easily, while major acid by-products such as lactic acid, acetic acid and formic acids were miscible in solution. By this one step recovery method, succinic acid yield was 70%, and the purity was 90%. In comparison, for traditional calcium precipitation coupled ion-exchange adsorption, the yield and purity were 52% and 92%, respectively. Crystallization could be regarded as not only the final purification step but also the first recovery step for the downstream separation process. In this study, succinic acid can be feasibly purified from fermentation broths selectively, which could be integrated with other separation method to optimize the downstream process. (C) 2010 Elsevier B.V. All rights reserved.
KeywordCrystallization Succinic Acid Ph Temperature
WOS HeadingsScience & Technology ; Technology
Indexed BySCI
WOS Research AreaEngineering
WOS SubjectEngineering, Chemical
WOS IDWOS:000277662200010
Citation statistics
Cited Times:78[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorXing, JM
Affiliation1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Inst Proc Engn, Key Lab Green Proc & Engn, Beijing 100190, Peoples R China
4.China Univ Min & Technol Beijing, Sch Chem & Environm Engn, Dept Bioengn, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Li, Qiang,Wang, Dan,Wu, Yong,et al. One step recovery of succinic acid from fermentation broths by crystallization[J]. SEPARATION AND PURIFICATION TECHNOLOGY,2010,72(3):294-300.
APA Li, Qiang.,Wang, Dan.,Wu, Yong.,Li, Wangliang.,Zhang, Yunjian.,...&Xing, JM.(2010).One step recovery of succinic acid from fermentation broths by crystallization.SEPARATION AND PURIFICATION TECHNOLOGY,72(3),294-300.
MLA Li, Qiang,et al."One step recovery of succinic acid from fermentation broths by crystallization".SEPARATION AND PURIFICATION TECHNOLOGY 72.3(2010):294-300.
Files in This Item:
File Name/Size DocType Version Access License
20131119-1254-复件 1-s(886KB) 限制开放CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Li, Qiang]'s Articles
[Wang, Dan]'s Articles
[Wu, Yong]'s Articles
Baidu academic
Similar articles in Baidu academic
[Li, Qiang]'s Articles
[Wang, Dan]'s Articles
[Wu, Yong]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Li, Qiang]'s Articles
[Wang, Dan]'s Articles
[Wu, Yong]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.