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Preparation of alginate coated chitosan hydrogel beads by thermosensitive internal gelation technique
Zhao, Qing Sheng1,2,3; Ji, Qiu Xia4; Cheng, Xiao Jie1; Sun, Gang Zheng1; Ran, Chao1; Zhao, Bing2; Chen, Xi Guang1; Chen, XG
2010-05-01
Source PublicationJOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
ISSN0928-0707
Volume54Issue:2Pages:232-237
AbstractChitosan hydrogel beads were successfully prepared by the method of thermosensitive internal gelation technique. The prepared beads were spherical, smooth-surfaced and non-aggregated with a diameter of 1.7-2.1 mm. The diameters of beads can be controlled and have a correlation with the initial drop size, the concentration of CaCl2, alginate and the time of solidification. The bead is comprised of three parts, which are chitosan/glycerophosphate (CS/GP) hydrogel core, chitosan-alginate (CS/SA) gel layer in the middle and calcium-alginate gelatin capsules in outer layer. Swelling studies indicate that the beads can be stable in simulated gastric fluid. But the beads shrink sharply when removed to simulated intestinal fluid. Drug release behavior showed that release of ornidazole in the beads is much slower than in the CS/GP hydrogel.
KeywordChitosan Sodium Alginate Hydrogel Beads Thermosensitive
SubtypeArticle
WOS HeadingsScience & Technology ; Technology
DOI10.1007/s10971-010-2187-8
Indexed BySCI
Language英语
WOS KeywordDRUG-DELIVERY SYSTEM ; BETA-GLYCEROPHOSPHATE ; IN-SITU ; CONTROLLED-RELEASE ; SODIUM-ALGINATE ; CELLS ; TEMPERATURE ; SCAFFOLDS ; MEMBRANE ; SURVIVAL
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, Ceramics
WOS IDWOS:000277025200012
Citation statistics
Cited Times:16[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.ipe.ac.cn/handle/122111/6160
Collection生化工程国家重点实验室
Corresponding AuthorChen, XG
Affiliation1.Ocean Univ China, Coll Marine Life Sci, Qingdao 266003, Peoples R China
2.Chinese Acad Sci, Natl Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
4.Qingdao Univ, Coll Med, Affiliated Hosp, Qingdao 266001, Peoples R China
Recommended Citation
GB/T 7714
Zhao, Qing Sheng,Ji, Qiu Xia,Cheng, Xiao Jie,et al. Preparation of alginate coated chitosan hydrogel beads by thermosensitive internal gelation technique[J]. JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY,2010,54(2):232-237.
APA Zhao, Qing Sheng.,Ji, Qiu Xia.,Cheng, Xiao Jie.,Sun, Gang Zheng.,Ran, Chao.,...&Chen, XG.(2010).Preparation of alginate coated chitosan hydrogel beads by thermosensitive internal gelation technique.JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY,54(2),232-237.
MLA Zhao, Qing Sheng,et al."Preparation of alginate coated chitosan hydrogel beads by thermosensitive internal gelation technique".JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY 54.2(2010):232-237.
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