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A novel continuous re-extraction procedure of penicillin G by a micro-extractor based on ceramic membrane
Wu, Yong1,2; Li, Wangliang2,3; Gao, Hongshuai1,2; Li, Qiang2,3; Li, Yuguang1,2; Wang, Kang1,2; Mahmood, Iram1,2; Liu, Huizhou1; Liu, H
2010-02-01
Source PublicationJOURNAL OF MEMBRANE SCIENCE
ISSN0376-7388
Volume347Issue:1-2Pages:17-25
AbstractA ceramic membrane micro-extractor (CME), employed for continuous re-extraction of penicillin G (PEN G), was studied systematically. The droplet size was investigated in the re-extraction process. Re-extraction efficiency (RE) and degradation rate of PEN G were extensively examined by superficial Reynolds number (Re(h)), phase ratio (R), initial PEN G concentration and membrane pore size. To further understand and quantitatively analyze the re-extraction behavior, resistance-in-series (RIS) model was developed to predict the re-extraction efficiency at steady-state conditions. First of all, a three-parameter correlation was defined for quantitative description of droplet size. The main factors affecting the re-extraction efficiency of PEN G were superficial Reynolds number and phase ratio. The re-extraction efficiency of PEN G reached 99% or above at Re(h) > 934 and R > 0.08. Meanwhile, the degradation rate of PEN G (D) decreased to 0.5% when Re(h) was 934. Compared with the re-extraction performance of the batch extractor, less residence time was needed and the degradation rate decreased 50%. The theoretical re-extraction efficiency (BET) was in good agreement with the experimental data. (C) 2009 Elsevier B.V. All rights reserved.
KeywordPenicillin g Micro-extraction Liquid Droplets Re-extraction Efficiency Degradation Modeling
SubtypeArticle
WOS HeadingsScience & Technology ; Technology ; Physical Sciences
DOI10.1016/j.memsci.2009.10.001
Indexed BySCI
Language英语
WOS KeywordCONTINUOUS REACTIVE EXTRACTION ; EMULSION LIQUID-MEMBRANE ; MASS-TRANSFER ; DISTRIBUTION COEFFICIENTS ; INTERFACIAL-TENSION ; HOLLOW-FIBER ; KARR COLUMN ; EMULSIFICATION ; SYSTEMS ; FLOW
WOS Research AreaEngineering ; Polymer Science
WOS SubjectEngineering, Chemical ; Polymer Science
WOS IDWOS:000273662200003
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.ipe.ac.cn/handle/122111/6219
Collection湿法冶金清洁生产技术国家工程实验室
Corresponding AuthorLiu, H
Affiliation1.Chinese Acad Sci, Inst Proc Engn, Key Lab Green Proc & Engn, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Wu, Yong,Li, Wangliang,Gao, Hongshuai,et al. A novel continuous re-extraction procedure of penicillin G by a micro-extractor based on ceramic membrane[J]. JOURNAL OF MEMBRANE SCIENCE,2010,347(1-2):17-25.
APA Wu, Yong.,Li, Wangliang.,Gao, Hongshuai.,Li, Qiang.,Li, Yuguang.,...&Liu, H.(2010).A novel continuous re-extraction procedure of penicillin G by a micro-extractor based on ceramic membrane.JOURNAL OF MEMBRANE SCIENCE,347(1-2),17-25.
MLA Wu, Yong,et al."A novel continuous re-extraction procedure of penicillin G by a micro-extractor based on ceramic membrane".JOURNAL OF MEMBRANE SCIENCE 347.1-2(2010):17-25.
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