| Hollow quaternized chitosan microspheres increase the therapeutic effect of orally administered insulin | |
| Wei, Wei1,2; Ma, Guang-Hui1; Wang, Lian-Yan1; Wu, Jie1; Su, Zhi-Guo1; Ma, GH | |
| 2010 | |
| Source Publication | ACTA BIOMATERIALIA
 |
| ISSN | 1742-7061 |
| Volume | 6Issue:1Pages:205-209 |
| Abstract | The delivery of insulin by non-parenteral routes has gained significant attention over the last two decades. In the present study, we prepared hollow quaternized chitosan microspheres by the SPG membrane emulsification technique and glutaraldehyde cross-linking method. The structural properties, as well as the uniform size and autofluorescence, enabled us to develop oral delivery of insulin which conserved the bioactivity of the encapsulated insulin, achieving bioadhesion of microspheres, increasing the loading ability and optimizing the release profile. In vivo evaluation also saw an optimal reduction in blood glucose level and powerful therapeutic effects after treatment with the designed microspheres, which further confirmed the feasibility of using hollow quaternized chitosan microspheres as insulin carriers for oral administration. (C) 2009 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. |
| Keyword | Chitosan Microspheres Insulin Oral Administration |
| Subtype | Article |
| WOS Headings | Science & Technology ; Technology |
| DOI | 10.1016/j.actbio.2009.06.005 |
| Indexed By | SCI |
| Language | 英语 |
| WOS Keyword | DRUG-DELIVERY ; MEMBRANE EMULSIFICATION ; DIABETIC-RATS ; PROTEIN DRUG ; IN-VITRO ; NANOPARTICLES ; DEGRADATION ; HYDROGELS ; SYSTEMS |
| WOS Research Area | Engineering ; Materials Science |
| WOS Subject | Engineering, Biomedical ; Materials Science, Biomaterials |
| WOS ID | WOS:000273087900024 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Version | 出版稿 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/6227 |
| Collection | 生化工程国家重点实验室 |
| Corresponding Author | Ma, GH |
| Affiliation | 1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| Recommended Citation GB/T 7714 | Wei, Wei,Ma, Guang-Hui,Wang, Lian-Yan,et al. Hollow quaternized chitosan microspheres increase the therapeutic effect of orally administered insulin[J]. ACTA BIOMATERIALIA,2010,6(1):205-209. |
| APA | Wei, Wei,Ma, Guang-Hui,Wang, Lian-Yan,Wu, Jie,Su, Zhi-Guo,&Ma, GH.(2010).Hollow quaternized chitosan microspheres increase the therapeutic effect of orally administered insulin.ACTA BIOMATERIALIA,6(1),205-209. |
| MLA | Wei, Wei,et al."Hollow quaternized chitosan microspheres increase the therapeutic effect of orally administered insulin".ACTA BIOMATERIALIA 6.1(2010):205-209. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| 20131127-1340-复件 1-s（441KB） | 限制开放 | CC BY-NC-SA | Application Full Text | |||
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