CAS OpenIR  > 生化工程国家重点实验室
Hollow quaternized chitosan microspheres increase the therapeutic effect of orally administered insulin
Wei, Wei1,2; Ma, Guang-Hui1; Wang, Lian-Yan1; Wu, Jie1; Su, Zhi-Guo1; Ma, GH
2010
Source PublicationACTA BIOMATERIALIA
ISSN1742-7061
Volume6Issue:1Pages:205-209
AbstractThe delivery of insulin by non-parenteral routes has gained significant attention over the last two decades. In the present study, we prepared hollow quaternized chitosan microspheres by the SPG membrane emulsification technique and glutaraldehyde cross-linking method. The structural properties, as well as the uniform size and autofluorescence, enabled us to develop oral delivery of insulin which conserved the bioactivity of the encapsulated insulin, achieving bioadhesion of microspheres, increasing the loading ability and optimizing the release profile. In vivo evaluation also saw an optimal reduction in blood glucose level and powerful therapeutic effects after treatment with the designed microspheres, which further confirmed the feasibility of using hollow quaternized chitosan microspheres as insulin carriers for oral administration. (C) 2009 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
KeywordChitosan Microspheres Insulin Oral Administration
SubtypeArticle
WOS HeadingsScience & Technology ; Technology
DOI10.1016/j.actbio.2009.06.005
Indexed BySCI
Language英语
WOS KeywordDRUG-DELIVERY ; MEMBRANE EMULSIFICATION ; DIABETIC-RATS ; PROTEIN DRUG ; IN-VITRO ; NANOPARTICLES ; DEGRADATION ; HYDROGELS ; SYSTEMS
WOS Research AreaEngineering ; Materials Science
WOS SubjectEngineering, Biomedical ; Materials Science, Biomaterials
WOS IDWOS:000273087900024
Citation statistics
Cited Times:43[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.ipe.ac.cn/handle/122111/6227
Collection生化工程国家重点实验室
Corresponding AuthorMa, GH
Affiliation1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Wei, Wei,Ma, Guang-Hui,Wang, Lian-Yan,et al. Hollow quaternized chitosan microspheres increase the therapeutic effect of orally administered insulin[J]. ACTA BIOMATERIALIA,2010,6(1):205-209.
APA Wei, Wei,Ma, Guang-Hui,Wang, Lian-Yan,Wu, Jie,Su, Zhi-Guo,&Ma, GH.(2010).Hollow quaternized chitosan microspheres increase the therapeutic effect of orally administered insulin.ACTA BIOMATERIALIA,6(1),205-209.
MLA Wei, Wei,et al."Hollow quaternized chitosan microspheres increase the therapeutic effect of orally administered insulin".ACTA BIOMATERIALIA 6.1(2010):205-209.
Files in This Item:
File Name/Size DocType Version Access License
20131127-1340-复件 1-s(441KB) 限制开放CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Wei, Wei]'s Articles
[Ma, Guang-Hui]'s Articles
[Wang, Lian-Yan]'s Articles
Baidu academic
Similar articles in Baidu academic
[Wei, Wei]'s Articles
[Ma, Guang-Hui]'s Articles
[Wang, Lian-Yan]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Wei, Wei]'s Articles
[Ma, Guang-Hui]'s Articles
[Wang, Lian-Yan]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.