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Anti-influenza agents from Traditional Chinese Medicine
Ge, Hu2; Wang, Yi-Fei1; Xu, Jun2; Gu, Qiong2; Liu, Hai-Bo3; Xiao, Pei-Gen3; Zhou, Jiaju4; Liu, Yanhuai5; Yang, Zirong6; Su, Hua6; Wang, YF
2010
Source PublicationNATURAL PRODUCT REPORTS
ISSN0265-0568
Volume27Issue:12Pages:1758-1780
AbstractAfter new human transmissible H1N1 (swine flu) viruses were reported in Mexico and the United States in April 2009, the World Health Organization (WHO) announced the emergence of a novel influenza A virus. Most governments in the world have been alerted and are monitoring the situation closely. As one of the official responses to the H1N1 pandemic, the Chinese government has released three editions of a document entitled "Recommended Schemes for Pandemic Influenza A Diagnoses and Treatments". The third edition recommended the use of not only two targeted anti-flu drugs, oseltamivir and zanamivir, but also four anti-flu TCM (Traditional Chinese Medicine) prescriptions. Since then, TCM has played a significant role in fighting the pandemic. TCM drugs comprise multiple compounds regulating multiple targets for a given class of medical indications, and are tunable to the symptoms of the individual. This review summarizes anti-influenza agents from TCM, including compounds, herbs, and TCM prescriptions, and suggests that, by further investigating TCM theory and mining TCM databases, a better drug discovery paradigm may arise - one that can be beneficial to both TCM and modern medicine.
KeywordInfluenza-virus Hemagglutinin a H5n1 Infection Neuraminidase Inhibitory-activity Respiratory Syncytial Virus X-ray Crystallography Semliki-forest-virus M2 Proton Channels In-vitro Membrane-fusion Sialic-acid
SubtypeReview
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
DOI10.1039/c0np00005a
Indexed BySCI
Language英语
WOS KeywordINFLUENZA-VIRUS HEMAGGLUTININ ; A H5N1 INFECTION ; NEURAMINIDASE INHIBITORY-ACTIVITY ; RESPIRATORY SYNCYTIAL VIRUS ; X-RAY CRYSTALLOGRAPHY ; SEMLIKI-FOREST-VIRUS ; M2 PROTON CHANNELS ; IN-VITRO ; MEMBRANE-FUSION ; SIALIC-ACID
WOS Research AreaBiochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Medicinal ; Chemistry, Organic
WOS IDWOS:000284317100002
Citation statistics
Cited Times:62[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.ipe.ac.cn/handle/122111/6254
Collection多相复杂系统国家重点实验室
Corresponding AuthorWang, YF
Affiliation1.Jinan Univ, Biomed Res & Dev Ctr, Guangzhou 510630, Guangdong, Peoples R China
2.Sun Yat Sen Univ, Sch Pharmaceut Sci, Res Ctr Drug Discovery, Guangzhou 510006, Guangdong, Peoples R China
3.Chinese Acad Med Sci, Chinese Peking Union Med Coll, Inst Med Plant Dev, Beijing 100193, Peoples R China
4.Chinese Acad Sci, Inst Proc Engn, Beijing 100190, Peoples R China
5.Eastlinden Technol Ltd, Beijing 100191, Peoples R China
6.Shanghai Innovat Res Ctr Tradit Chinese Med, Shanghai 201203, Peoples R China
Recommended Citation
GB/T 7714
Ge, Hu,Wang, Yi-Fei,Xu, Jun,et al. Anti-influenza agents from Traditional Chinese Medicine[J]. NATURAL PRODUCT REPORTS,2010,27(12):1758-1780.
APA Ge, Hu.,Wang, Yi-Fei.,Xu, Jun.,Gu, Qiong.,Liu, Hai-Bo.,...&Wang, YF.(2010).Anti-influenza agents from Traditional Chinese Medicine.NATURAL PRODUCT REPORTS,27(12),1758-1780.
MLA Ge, Hu,et al."Anti-influenza agents from Traditional Chinese Medicine".NATURAL PRODUCT REPORTS 27.12(2010):1758-1780.
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